Patterns of FGF family members binding to FGFR
| FGF . | FGFR1 IIIb . | FGFR1 IIIc . | FGFR2 IIIb . | FGFR2 IIIc . | FGFR3 IIIb . | FGFR3 IIIc . | FGFR4 . |
|---|---|---|---|---|---|---|---|
| FGF2 | ND | +++ | NB | +++ | M(−) | NB | ND |
| FGF4 | M(+) | ++ | ++ | +++ | M(−) | NB | M(+) |
| FGF7 | M(−) | NB | + | NB | M(−) | NB | M(−) |
| FGF9 | M(−) | + | NB | + | M(+) | NB | M(+) |
| FGF16 | ND | ND | ND | + | ND | ND | ND |
| FGF19 | ND | NB | ND | NB | ND | NB | ++ |
| FGF . | FGFR1 IIIb . | FGFR1 IIIc . | FGFR2 IIIb . | FGFR2 IIIc . | FGFR3 IIIb . | FGFR3 IIIc . | FGFR4 . |
|---|---|---|---|---|---|---|---|
| FGF2 | ND | +++ | NB | +++ | M(−) | NB | ND |
| FGF4 | M(+) | ++ | ++ | +++ | M(−) | NB | M(+) |
| FGF7 | M(−) | NB | + | NB | M(−) | NB | M(−) |
| FGF9 | M(−) | + | NB | + | M(+) | NB | M(+) |
| FGF16 | ND | ND | ND | + | ND | ND | ND |
| FGF19 | ND | NB | ND | NB | ND | NB | ++ |
NB indicates negligible binding; ND, not determined; M(+), mitogenic response in FGFR-overexpressing BaF3 cells; M(−), no mitogenic response of FGFR-overexpressing BaF3 cells; +++, strong binding; ++, intermediate binding; and +, weak binding.