Table 2

Fifty-two SAM-defined genes are differentially expressed in NPC, MGUS, and MM

Probe setSymbolFunctionMGUS vs NPC*
MM vs MGUS†
SAM scoreFold changeSAM scoreFold change
201486_at RCN2 Unknown; calcium binding, ER lumen 2.48 1.55 4.13 1.63 
202475_at NIFIE14 Unknown 2.30 1.51 4.00 1.67 
212846_at KIAA0179 Unknown; nucleolar protein 2.07 1.30 3.80 1.48 
225260_s_at MRPL32 Ribosomal protein 2.13 1.32 3.77 1.43 
222673_x_at TMEM57 Unknown; transmembrane protein 3.19 1.65 3.60 1.63 
228324_at C9orf41 Unknown 2.86 1.51 3.59 1.57 
225223_at SMAD5 Gene transcription 3.12 1.70 3.43 1.41 
212536_at ATP11B Cation transport ATPase 2.16 1.41 3.41 1.55 
203216_s_at MYO6 Recessive actin-based motor 1.98 1.57 3.35 1.91 
238761_at MED28 Gene transcription 3.43 1.80 3.32 1.77 
200910_at CCT3 Molecular chaperone 2.04 1.34 3.30 1.60 
231530_s_at C11orf1 Unknown 2.24 1.57 3.26 1.49 
221207_s_at NBEA Protein kinase A regulator 3.42 1.83 3.22 2.49 
200692_s_at HSPA9B Cell proliferation and cellular aging; chaperone. 2.05 1.55 3.18 1.36 
212038_s_at VDAC1 Ion channel for cytochrome c 2.62 1.56 3.17 1.42 
208308_s_at GPI Energy metabolism 1.97 1.48 3.17 1.48 
201013_s_at PA1CS DNA synthesis 2.81 1.43 3.17 1.45 
202708_s_at HIST2H2BE Chromosome organization and biogenesis 2.35 1.71 3.14 2.11 
215071_s_at HIST1H2AC Chromosome organization and biogenesis 3.47 3.62 3.13 1.97 
225361_x_at LOC159090 Unknown 3.43 1.68 3.11 1.53 
219366_at AVEN Antiapoptosis 2.63 1.76 3.10 1.47 
209398_at H1ST1H1C Chromosome organization and biogenesis 5.39 5.53 3.09 2.02 
221652_s_at C12orf11 Unknown; sarcoma antigen NY-SAR-95 2.07 1.37 3.06 1.57 
225028_at LOC550643 Unknown 3.83 2.01 3.03 1.45 
214214_s_at C1QBP Immunity 2.64 1.45 3.03 1.47 
201577_at NME1 Nucleotide biosynthesis 3.57 1.62 2.99 1.58 
218280_x_at H1ST2H2AA Chromosome organization and biogenesis 4.24 4.76 2.95 1.92 
201479_at DKC1 Telomere maintenance 2.24 1.42 2.92 1.43 
208864_s_at TXN Redox reactions 2.90 1.68 2.91 1.51 
212297_at ATP13A3 Cation transport 2.64 1.42 2.88 1.54 
222825_at OTUD6B Unknown 2.66 1.35 2.88 1.40 
209267_s_at SLC39A8 Ion transport 3.41 1.86 2.88 1.56 
217898_at C15orf24 Unknown 2.35 1.70 2.83 1.33 
210275_s_at ZA20D2 Unknown 2.27 1.36 2.81 1.37 
213485_s_at ABCC10 ATP-dependent efflux pump; multidrug resistance pump 3.17 1.51 2.76 1.34 
200994_at IPO7 Nuclear trafficking 2.08 1.46 2.72 1.37 
222428_s_at LARS Protein synthesis 3.64 1.68 2.71 1.32 
202591_s_at SSBP1 Mitochondrial DNA replication 2.22 1.42 2.69 1.35 
204244_s_at ASK Cell cycle 3.25 1.77 2.67 1.37 
225916_at ZNF131 Gene transcription 2.47 1.39 2.63 1.36 
202396_at TCERG1 Gene transcription 3.85 1.62 2.63 1.32 
213340_s_at K1AA0495 Unknown −2.40 0.78 −2.52 0.75 
206150_at TNFRSF7 Immune cell signaling −3.82 0.55 −2.56 0.75 
228139_at RIPK3 Cell signaling −2.63 0.74 −2.59 0.77 
220066_at CARD15 Antiapoptosis −4.02 0.50 −2.66 0.62 
210347_s_at BCL11A Gene transcription 3.48 2.04 −2.67 0.64 
232511_at RANBP2L1 Nuclear import 2.07 1.54 −2.71 0.64 
214041_x_at RPL37A Ribosomal protein 2.22 1.80 −3.09 0.60 
219371_s_at KLF2 Gene transcription 3.81 1.78 −3.11 0.66 
202724_s_at FOXO1A Gene transcription 2.49 1.55 −3.27 0.64 
215671_at PDE4B Drug metabolism 2.07 1.53 −3.30 0.59 
219675_s_at UXS1 Glycosaminoglycan biosynthesis −2.33 0.76 2.97 1.35 
Probe setSymbolFunctionMGUS vs NPC*
MM vs MGUS†
SAM scoreFold changeSAM scoreFold change
201486_at RCN2 Unknown; calcium binding, ER lumen 2.48 1.55 4.13 1.63 
202475_at NIFIE14 Unknown 2.30 1.51 4.00 1.67 
212846_at KIAA0179 Unknown; nucleolar protein 2.07 1.30 3.80 1.48 
225260_s_at MRPL32 Ribosomal protein 2.13 1.32 3.77 1.43 
222673_x_at TMEM57 Unknown; transmembrane protein 3.19 1.65 3.60 1.63 
228324_at C9orf41 Unknown 2.86 1.51 3.59 1.57 
225223_at SMAD5 Gene transcription 3.12 1.70 3.43 1.41 
212536_at ATP11B Cation transport ATPase 2.16 1.41 3.41 1.55 
203216_s_at MYO6 Recessive actin-based motor 1.98 1.57 3.35 1.91 
238761_at MED28 Gene transcription 3.43 1.80 3.32 1.77 
200910_at CCT3 Molecular chaperone 2.04 1.34 3.30 1.60 
231530_s_at C11orf1 Unknown 2.24 1.57 3.26 1.49 
221207_s_at NBEA Protein kinase A regulator 3.42 1.83 3.22 2.49 
200692_s_at HSPA9B Cell proliferation and cellular aging; chaperone. 2.05 1.55 3.18 1.36 
212038_s_at VDAC1 Ion channel for cytochrome c 2.62 1.56 3.17 1.42 
208308_s_at GPI Energy metabolism 1.97 1.48 3.17 1.48 
201013_s_at PA1CS DNA synthesis 2.81 1.43 3.17 1.45 
202708_s_at HIST2H2BE Chromosome organization and biogenesis 2.35 1.71 3.14 2.11 
215071_s_at HIST1H2AC Chromosome organization and biogenesis 3.47 3.62 3.13 1.97 
225361_x_at LOC159090 Unknown 3.43 1.68 3.11 1.53 
219366_at AVEN Antiapoptosis 2.63 1.76 3.10 1.47 
209398_at H1ST1H1C Chromosome organization and biogenesis 5.39 5.53 3.09 2.02 
221652_s_at C12orf11 Unknown; sarcoma antigen NY-SAR-95 2.07 1.37 3.06 1.57 
225028_at LOC550643 Unknown 3.83 2.01 3.03 1.45 
214214_s_at C1QBP Immunity 2.64 1.45 3.03 1.47 
201577_at NME1 Nucleotide biosynthesis 3.57 1.62 2.99 1.58 
218280_x_at H1ST2H2AA Chromosome organization and biogenesis 4.24 4.76 2.95 1.92 
201479_at DKC1 Telomere maintenance 2.24 1.42 2.92 1.43 
208864_s_at TXN Redox reactions 2.90 1.68 2.91 1.51 
212297_at ATP13A3 Cation transport 2.64 1.42 2.88 1.54 
222825_at OTUD6B Unknown 2.66 1.35 2.88 1.40 
209267_s_at SLC39A8 Ion transport 3.41 1.86 2.88 1.56 
217898_at C15orf24 Unknown 2.35 1.70 2.83 1.33 
210275_s_at ZA20D2 Unknown 2.27 1.36 2.81 1.37 
213485_s_at ABCC10 ATP-dependent efflux pump; multidrug resistance pump 3.17 1.51 2.76 1.34 
200994_at IPO7 Nuclear trafficking 2.08 1.46 2.72 1.37 
222428_s_at LARS Protein synthesis 3.64 1.68 2.71 1.32 
202591_s_at SSBP1 Mitochondrial DNA replication 2.22 1.42 2.69 1.35 
204244_s_at ASK Cell cycle 3.25 1.77 2.67 1.37 
225916_at ZNF131 Gene transcription 2.47 1.39 2.63 1.36 
202396_at TCERG1 Gene transcription 3.85 1.62 2.63 1.32 
213340_s_at K1AA0495 Unknown −2.40 0.78 −2.52 0.75 
206150_at TNFRSF7 Immune cell signaling −3.82 0.55 −2.56 0.75 
228139_at RIPK3 Cell signaling −2.63 0.74 −2.59 0.77 
220066_at CARD15 Antiapoptosis −4.02 0.50 −2.66 0.62 
210347_s_at BCL11A Gene transcription 3.48 2.04 −2.67 0.64 
232511_at RANBP2L1 Nuclear import 2.07 1.54 −2.71 0.64 
214041_x_at RPL37A Ribosomal protein 2.22 1.80 −3.09 0.60 
219371_s_at KLF2 Gene transcription 3.81 1.78 −3.11 0.66 
202724_s_at FOXO1A Gene transcription 2.49 1.55 −3.27 0.64 
215671_at PDE4B Drug metabolism 2.07 1.53 −3.30 0.59 
219675_s_at UXS1 Glycosaminoglycan biosynthesis −2.33 0.76 2.97 1.35 

Genes are ordered based on the SAM score in the MM vs MGUS comparison.

*

Positive SAM score in the MGUS vs NPC column indicates the gene expression is higher in MGUS than in NPC.

†

Positive SAM score in the MM vs MGUS column indicates the gene is higher in MM than in MGUS.

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