Characteristics of patients with MGUS, SMM, MM from MGUS, TT1, TT2, and TT3 at diagnosis
| Characteristics* . | MGUS . | SMM . | MM from MGUS . | TT1 MM . | TT2 MM . | TT3 MM . | P . |
|---|---|---|---|---|---|---|---|
| N | 44 | 12 | 16 | 20 | 351 | 214 | — |
| Age 65 and older | 36 | 25 | 63 | 5 | 23 | 30 | .001 |
| Female sex | 45 | 58 | 25 | 45 | 43 | 35 | NS |
| White race | 84 | 92 | 25 | 80 | 89 | 89 | < .001 |
| IgA isotype | 12 | 25 | 19 | 15 | 25 | 20 | NS |
| B2M ≥ 3.0 mg/L | 11 | 17 | 64 | 45 | 49 | 57 | < .001* |
| C-reactive protein ≥ 8.0 mg/L | 21 | 25 | 25 | 20 | 36 | 32 | NS |
| Creatinine ≥ 2.0 mg/dL | 2 | 0 | 7 | 5 | 11 | 8 | NS |
| Lactate dehydrogenase ≥ 210 IU/L | 5 | 17 | 15 | 5 | 22 | 19 | .041 |
| Albumin < 3.5 g/dL | 2 | 8 | 6 | 30 | 14 | 14 | .049 |
| Hemoglobin < 10 g/dL | 2 | 0 | 13 | 25 | 26 | 31 | < .001 |
| Cytogenetic abnormalities | 0 | 0 | 6 | 20 | 34 | 31 | < .001 |
| Plasma cells (aspirate) > 10% | 0 | 100 | 46 | 95 | 91 | 90 | < .001 |
| MR1 ≥ 1 | 0 | 25 | 25 | 62 | 72 | 73 | < .001 |
| Characteristics* . | MGUS . | SMM . | MM from MGUS . | TT1 MM . | TT2 MM . | TT3 MM . | P . |
|---|---|---|---|---|---|---|---|
| N | 44 | 12 | 16 | 20 | 351 | 214 | — |
| Age 65 and older | 36 | 25 | 63 | 5 | 23 | 30 | .001 |
| Female sex | 45 | 58 | 25 | 45 | 43 | 35 | NS |
| White race | 84 | 92 | 25 | 80 | 89 | 89 | < .001 |
| IgA isotype | 12 | 25 | 19 | 15 | 25 | 20 | NS |
| B2M ≥ 3.0 mg/L | 11 | 17 | 64 | 45 | 49 | 57 | < .001* |
| C-reactive protein ≥ 8.0 mg/L | 21 | 25 | 25 | 20 | 36 | 32 | NS |
| Creatinine ≥ 2.0 mg/dL | 2 | 0 | 7 | 5 | 11 | 8 | NS |
| Lactate dehydrogenase ≥ 210 IU/L | 5 | 17 | 15 | 5 | 22 | 19 | .041 |
| Albumin < 3.5 g/dL | 2 | 8 | 6 | 30 | 14 | 14 | .049 |
| Hemoglobin < 10 g/dL | 2 | 0 | 13 | 25 | 26 | 31 | < .001 |
| Cytogenetic abnormalities | 0 | 0 | 6 | 20 | 34 | 31 | < .001 |
| Plasma cells (aspirate) > 10% | 0 | 100 | 46 | 95 | 91 | 90 | < .001 |
| MR1 ≥ 1 | 0 | 25 | 25 | 62 | 72 | 73 | < .001 |
P values were determined by Fisher exact test or χ2 analysis. Values represent the percentages of patients with the specified variable.
— indicates not applicable.
Conversion factors for SI units: multiply B2M values by 85 for conversion to nM; multiply creatinine values by 88.4 for conversion to μM; multiply albumin values by 10 for conversion to g/L; and multiply hemoglobin values by 10 for conversion to g/L.