Univariate analysis of response and OS by baseline risk factor in all 158 AML patients
| Risk factor . | No. of patients . | CR, no. (%) . | PR/HI, no. (%) . | Median OS, d (95% CI) . | P for OS . |
|---|---|---|---|---|---|
| Age | < .001 | ||||
| Younger than 75 y | 83 | 13 (16) | 11 (13) | 248 (159-319) | |
| 75 y or older | 75 | 9 (12) | 4 (5) | 108 (78-157) | |
| ECOG PS | < .001 | ||||
| 0-1 | 137 | 21 (15) | 14 (10) | 172 (151-228) | |
| 2 | 16 | 1 (6) | 1 (6) | 53 (41-164) | |
| Unfavorable karyotype | .01 | ||||
| Yes | 75 | 10 (13) | 7 (9) | 118 (91-159) | |
| No | 72 | 11 (15) | 8 (11) | 218 (154-273) | |
| Organ dysfunction | .108 | ||||
| Yes | 94 | 14 (15) | 8 (9) | 166 (125-254) | |
| No | 64 | 8 (13) | 7 (11) | 157 (111-193) | |
| Prior MDS | .003 | ||||
| Yes | 119 | 18 (15) | 12 (10) | 189 (152-248) | |
| No | 39 | 4 (10) | 3 (7) | 108 (44-158) | |
| Baseline blasts in marrow | < .001 | ||||
| Less than 40% | 70 | 10 (14) | 10 (14) | 242 (172-372) | |
| 40% or more | 85 | 12 (14) | 5 (6) | 107 (66-153) | |
| Time from diagnosis to treatment | .865 | ||||
| 13 d or less | 98 | 11 (11) | 10 (10) | 167 (151-228) | |
| More than 13 d | 52 | 9 (17) | 5 (10) | 152 (91-222) | |
| WBC count | .06 | ||||
| More than 30 × 109/L | 10 | 0 (0) | 14 (9) | 113 (53-248) | |
| 30 × 109/L or less | 148 | 22 (100) | 1 (10) | 166 (151-209) |
| Risk factor . | No. of patients . | CR, no. (%) . | PR/HI, no. (%) . | Median OS, d (95% CI) . | P for OS . |
|---|---|---|---|---|---|
| Age | < .001 | ||||
| Younger than 75 y | 83 | 13 (16) | 11 (13) | 248 (159-319) | |
| 75 y or older | 75 | 9 (12) | 4 (5) | 108 (78-157) | |
| ECOG PS | < .001 | ||||
| 0-1 | 137 | 21 (15) | 14 (10) | 172 (151-228) | |
| 2 | 16 | 1 (6) | 1 (6) | 53 (41-164) | |
| Unfavorable karyotype | .01 | ||||
| Yes | 75 | 10 (13) | 7 (9) | 118 (91-159) | |
| No | 72 | 11 (15) | 8 (11) | 218 (154-273) | |
| Organ dysfunction | .108 | ||||
| Yes | 94 | 14 (15) | 8 (9) | 166 (125-254) | |
| No | 64 | 8 (13) | 7 (11) | 157 (111-193) | |
| Prior MDS | .003 | ||||
| Yes | 119 | 18 (15) | 12 (10) | 189 (152-248) | |
| No | 39 | 4 (10) | 3 (7) | 108 (44-158) | |
| Baseline blasts in marrow | < .001 | ||||
| Less than 40% | 70 | 10 (14) | 10 (14) | 242 (172-372) | |
| 40% or more | 85 | 12 (14) | 5 (6) | 107 (66-153) | |
| Time from diagnosis to treatment | .865 | ||||
| 13 d or less | 98 | 11 (11) | 10 (10) | 167 (151-228) | |
| More than 13 d | 52 | 9 (17) | 5 (10) | 152 (91-222) | |
| WBC count | .06 | ||||
| More than 30 × 109/L | 10 | 0 (0) | 14 (9) | 113 (53-248) | |
| 30 × 109/L or less | 148 | 22 (100) | 1 (10) | 166 (151-209) |
WBC indicates white blood cell.