Clinical and cytogenetic characteristics of patients achieving CR with tipifarnib
| Age, y/sex . | Prior MDS . | PS . | Comorbidities . | Cytogenetics . | Duration of CR, mo . | OS, mo . |
|---|---|---|---|---|---|---|
| 74/F | No | 0 | HBP, DM with neuropathies | 46XX | 8.5 | 9.7 |
| 81/M | No | 1 | HBP, AF, PD, diverticulitis | 47XY, +8 | 1.9 | 5 |
| 68/M | Yes | 1 | Prostate cancer, pelvic XRT | 46XY | 7.3 | 38.7 |
| 73/M | Yes | 0 | COPD with asthma, s/p silent MI, CAD | 46XY, −7q11.2 | 6 | 19 |
| 80/M | Yes | 1 | BOOP, HBP/CAD | 46XY, −6q21 | 1.2; died in CR, cycle 2 | 2.2 |
| 67/M | Yes | 0 | Pneumonia | 46XY | 9.8 | 14.4 |
| 82/M | No | 1 | HBP, DM, diverticulitis | 46XY | 12.5 | 18.3 |
| 85/M | Yes | 1 | Prostate cancer, pelvic XRT | 46XY | 5.1 | 12.9 |
| 82/M | Yes | 2 | Alveolar hemorrhage, CAD, h/o AF, HBP | 47-94XY-XXYY, −7q, +13; subclone: −5, −7, +13, +13, +13, 1-2 markers | 3.3 | 7 |
| 73/M | Yes | 1 | HBP, CAD, AF | 46XY | 4.5 | 18.9+ |
| 69/F | Yes | 1 | PD, OBS | 46XX | 15.8 | 33+ |
| 74/F | No | 1 | Diverticulitis, hypothyroidism | 46XX, Ph+ | 13 | 32.8+ |
| 76/M | Yes | 0 | Carotid endarterectomy | 46XY | 4.6 | 14.3 |
| 70/M | Yes | 1 | Asthma/COPD, DM with retinopathy, h/o malaria | 46XY | 6.6 | 39+ |
| 71/M | Yes | 1 | None | 46XY | 5.6 | 22.4+ |
| 79/M | Yes | 1 | h/o prostate cancer | 46XY | 3.9 | 19.1 |
| 69/M | Yes | 1 | HBP, BPH | 46XY | 1.1 | 13 |
| 79/M | Yes | 1 | HBP, CHF, gout, BPH (requiring catheter) | 46XY, −7q | 4 | 9.3 |
| 82/F | Yes | 2 | CAD, s/p MI, HBP, diabetes | 46XX | 4.2 | 8.6 |
| 70/M | Yes | 0 | Diverticulitis, HBP | 47XY, +8 | 9.2 | 39.2 |
| 65/M | Yes | 1 | AF, HBP, arthritis | 46XY, inv(12) | 9.1 | 18.8 |
| 73/F | Yes | 1 | HBP, h/o GI bleed, h/o breast cancer | 47XX, +8 | 4 | 13.2 |
| Age, y/sex . | Prior MDS . | PS . | Comorbidities . | Cytogenetics . | Duration of CR, mo . | OS, mo . |
|---|---|---|---|---|---|---|
| 74/F | No | 0 | HBP, DM with neuropathies | 46XX | 8.5 | 9.7 |
| 81/M | No | 1 | HBP, AF, PD, diverticulitis | 47XY, +8 | 1.9 | 5 |
| 68/M | Yes | 1 | Prostate cancer, pelvic XRT | 46XY | 7.3 | 38.7 |
| 73/M | Yes | 0 | COPD with asthma, s/p silent MI, CAD | 46XY, −7q11.2 | 6 | 19 |
| 80/M | Yes | 1 | BOOP, HBP/CAD | 46XY, −6q21 | 1.2; died in CR, cycle 2 | 2.2 |
| 67/M | Yes | 0 | Pneumonia | 46XY | 9.8 | 14.4 |
| 82/M | No | 1 | HBP, DM, diverticulitis | 46XY | 12.5 | 18.3 |
| 85/M | Yes | 1 | Prostate cancer, pelvic XRT | 46XY | 5.1 | 12.9 |
| 82/M | Yes | 2 | Alveolar hemorrhage, CAD, h/o AF, HBP | 47-94XY-XXYY, −7q, +13; subclone: −5, −7, +13, +13, +13, 1-2 markers | 3.3 | 7 |
| 73/M | Yes | 1 | HBP, CAD, AF | 46XY | 4.5 | 18.9+ |
| 69/F | Yes | 1 | PD, OBS | 46XX | 15.8 | 33+ |
| 74/F | No | 1 | Diverticulitis, hypothyroidism | 46XX, Ph+ | 13 | 32.8+ |
| 76/M | Yes | 0 | Carotid endarterectomy | 46XY | 4.6 | 14.3 |
| 70/M | Yes | 1 | Asthma/COPD, DM with retinopathy, h/o malaria | 46XY | 6.6 | 39+ |
| 71/M | Yes | 1 | None | 46XY | 5.6 | 22.4+ |
| 79/M | Yes | 1 | h/o prostate cancer | 46XY | 3.9 | 19.1 |
| 69/M | Yes | 1 | HBP, BPH | 46XY | 1.1 | 13 |
| 79/M | Yes | 1 | HBP, CHF, gout, BPH (requiring catheter) | 46XY, −7q | 4 | 9.3 |
| 82/F | Yes | 2 | CAD, s/p MI, HBP, diabetes | 46XX | 4.2 | 8.6 |
| 70/M | Yes | 0 | Diverticulitis, HBP | 47XY, +8 | 9.2 | 39.2 |
| 65/M | Yes | 1 | AF, HBP, arthritis | 46XY, inv(12) | 9.1 | 18.8 |
| 73/F | Yes | 1 | HBP, h/o GI bleed, h/o breast cancer | 47XX, +8 | 4 | 13.2 |
For OS, a plus following the value indicates still alive as of December 31, 2005.
HBP indicates high blood pressure; DM, diabetes mellitus; AF, atrial fibrillation; PD, Parkinson disease; XRT, x-ray therapy; COPD, chronic obstructive pulmonary disease; s/p, status after; MI, myocardial infarction; CAD, coronary artery disease; BOOP, bronchiolitis obliterans-organizing pneumonia; h/o, history of; OBS, organic brain syndrome; BPH, benign prostatic hypertrophy; CHF, congestive heart failure; and GI, gastrointestinal.