Summary of functional responses of HRS cell lines to BAFF and APRIL
| Functional responses to BAFF or APRIL . | HRS cell lines . | |||
|---|---|---|---|---|
| HD-MyZ . | HD-LM2 . | L428 . | L1236 . | |
| BAFF-mediated increase of viable cells | +* | −† | + | + |
| BAFF-mediated decrease of apoptotic cells | +‡ | − | + | − |
| BAFF-mediated induction of DNA synthesis | + | − | + | − |
| APRIL-mediated increase of viable cells | + | − | + | + |
| APRIL-mediated decrease of apoptotic cells | + | − | + | + |
| APRIL-mediated induction of DNA synthesis | +++ | ND | ++ | + |
| Functional responses to BAFF or APRIL . | HRS cell lines . | |||
|---|---|---|---|---|
| HD-MyZ . | HD-LM2 . | L428 . | L1236 . | |
| BAFF-mediated increase of viable cells | +* | −† | + | + |
| BAFF-mediated decrease of apoptotic cells | +‡ | − | + | − |
| BAFF-mediated induction of DNA synthesis | + | − | + | − |
| APRIL-mediated increase of viable cells | + | − | + | + |
| APRIL-mediated decrease of apoptotic cells | + | − | + | + |
| APRIL-mediated induction of DNA synthesis | +++ | ND | ++ | + |
The functional responses were all positive for the KM-H2 cell line.
ND indicates not determined.
Increased viability under serum starvation conditions.
†No detectable response.
‡Decreased apoptosis under serum starvation conditions.