Table 2 Clinical characteristics,... | American Society of Hematology

Table 2

Clinical characteristics, histologic subtype, and TACI, BCMA, BAFF-R, BAFF and APRIL expression profiles of classical HL cases

Case no.	Age, y*	Sex	Subtype†	EBV‡	TACI§	BCMA§	BAFF∥	APRIL∥
1	10	F	NS	+	+	+	+	+
2	47	M	NS	−	+	+	+	+
3	32	M	NS	−	+	+	+	+
4	24	M	NS	+	+/−	−	+	+
5	52	F	MC	+	+/−	+/−	+	+/−
6	24	M	MC	−	+	+	+/−	+/−
7	50	F	MC	+	+	−	+/−	+
8	30	M	NS	−	+	+	+	+
9	76	M	NS	−	+	−	+	+
10	37	F	NS	−	+	+	+	+
11	38	M	LD	−	+	+	+	+
12	23	F	NS	−	−	−	+	+/−
13	33	F	NS	−	+	+	+	+
14	35	F	NS	−	+/−	+/−	+	+/−
15	66	M	NS	−	+/−	−	+/−	+/−

Case no.	Age, y*	Sex	Subtype†	EBV‡	TACI§	BCMA§	BAFF∥	APRIL∥
1	10	F	NS	+	+	+	+	+
2	47	M	NS	−	+	+	+	+
3	32	M	NS	−	+	+	+	+
4	24	M	NS	+	+/−	−	+	+
5	52	F	MC	+	+/−	+/−	+	+/−
6	24	M	MC	−	+	+	+/−	+/−
7	50	F	MC	+	+	−	+/−	+
8	30	M	NS	−	+	+	+	+
9	76	M	NS	−	+	−	+	+
10	37	F	NS	−	+	+	+	+
11	38	M	LD	−	+	+	+	+
12	23	F	NS	−	−	−	+	+/−
13	33	F	NS	−	+	+	+	+
14	35	F	NS	−	+/−	+/−	+	+/−
15	66	M	NS	−	+/−	−	+/−	+/−

All HL cases were negative for BAFF-R.

*Mean age, 38.5 years (range, 10-76 years).

†NS indicates nodular sclerosis; MC, mixed cellularity; and LD, lymphocyte depletion.

‡EBV was detected by staining tissue sections for the EBV protein latent-membrane protein-1.

§TACI, BCMA, and BAFF-R expression by CD30⁺ cells with canonical HRS morphology.

∥BAFF and APRIL expression by CD30⁺ cells with canonical HRS morphology. All HL cases comprised abundant reactive cells expressing BAFF and/or APRIL.