Table 4. Most common (occurring in at... | American Society of Hematology

Table 4.

Most common (occurring in at least 30% of patients) AEs (n = 60) and comparison of rates of grade 3/4 AEs in the first 2 cycles versus in the third cycle onward and in patients aged less than 75 years versus in patients aged 75 years or more

	Overall toxicities			Grade 3/4 AEs by treatment cycle			Grade 3/4 AEs by patient age
AE	All grades, %	Grade 3/4, %	First and second cycles, %	Third cycle onward, %	Less than 75 y, %	75 y or more, %
Anemia	86	10	8	0	5	16
Thrombocytopenia	93	51	33	17	52	50
Infection	75	16	12	4	5	25
Neutropenia	85	43	33	24	36	50
Asthenia	63	5	4	2	0	12
Nausea	55	2	2	0	0	4
Diarrhea	55	16	8	2	17	16
Peripheral neuropathy	55	17	8	6	14	25
Constipation	52	8	6	2	3	16
Anorexia	38	2	2	0	0	4
Vomiting	30	2	2	0	0	4

	Overall toxicities			Grade 3/4 AEs by treatment cycle			Grade 3/4 AEs by patient age
AE	All grades, %	Grade 3/4, %	First and second cycles, %	Third cycle onward, %	Less than 75 y, %	75 y or more, %
Anemia	86	10	8	0	5	16
Thrombocytopenia	93	51	33	17	52	50
Infection	75	16	12	4	5	25
Neutropenia	85	43	33	24	36	50
Asthenia	63	5	4	2	0	12
Nausea	55	2	2	0	0	4
Diarrhea	55	16	8	2	17	16
Peripheral neuropathy	55	17	8	6	14	25
Constipation	52	8	6	2	3	16
Anorexia	38	2	2	0	0	4
Vomiting	30	2	2	0	0	4