Table 3.

Response rates among subgroups of patients according to Rb IgH translocations, determined by FISH




Rb deletion

No Rb deletion

IgH

No IgH
No. patients   13   20   8   20  
Response rate, %  100*  66   88  82  
    IF-negative CR   42   30   25   41  
    IF-positive CR   15   5   13   5  
    PR   46   35   50   36  
Stable disease, %
 
0
 
30
 
13
 
18
 



Rb deletion

No Rb deletion

IgH

No IgH
No. patients   13   20   8   20  
Response rate, %  100*  66   88  82  
    IF-negative CR   42   30   25   41  
    IF-positive CR   15   5   13   5  
    PR   46   35   50   36  
Stable disease, %
 
0
 
30
 
13
 
18
 

Patients were treated at the 1.3 mg/m2 bortezomib dose level.

CR indicates complete response; IF, immunofixation; PR, partial response.

*

P = .16 versus no Rb deletion.

P = .7 versus no IgH translocation.

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