Response rates after 1 cycle of VMP and best response after a median of 7 cycles of VMP or 6 or 12 cycles of MP (historical control data)
. | VMP . | . | Historical MP . | . | ||
|---|---|---|---|---|---|---|
. | First cycle . | Best response after a median of 7 cycles . | Best response after 6 cycles*41 . | Best response after 12 cycles*41 . | ||
| Overall response rate, % | 70 | 89 | 42 | 35 | ||
| IF-negative CR | 6 | 32 | 0 | 0 | ||
| IF-positive CR | 2 | 11 | 3 | 9 | ||
| PR | 62 | 45 | 39 | 26 | ||
| Minor response, % | 6 | 0 | 27 | 14 | ||
| Stable disease, % | 24 | 11 | 31† | NA | ||
. | VMP . | . | Historical MP . | . | ||
|---|---|---|---|---|---|---|
. | First cycle . | Best response after a median of 7 cycles . | Best response after 6 cycles*41 . | Best response after 12 cycles*41 . | ||
| Overall response rate, % | 70 | 89 | 42 | 35 | ||
| IF-negative CR | 6 | 32 | 0 | 0 | ||
| IF-positive CR | 2 | 11 | 3 | 9 | ||
| PR | 62 | 45 | 39 | 26 | ||
| Minor response, % | 6 | 0 | 27 | 14 | ||
| Stable disease, % | 24 | 11 | 31† | NA | ||
For VMP, n = 53; for historical MP, best response after 6 cycles, n = 87; for historical MP, best response after 12 cycles, n = 77.
CR indicates complete response; IF, immunofixation; PR, partial response; and NA, not available.
Cycles were 4 weeks in duration; MP administered at the same dose as in the VMP regimen.
Or PD.