Table 1. Blood-derived CD133 cells yield... | American Society of Hematology

Table 1.

Blood-derived CD133⁺ cells yield human Dys3⁺ myofibers within injected dystrophic muscles after intra-arterial transplantation of unexercised and exercised scid/mdx mice

	Quadriceps			Soleus
Positive myofibers	Unexercised	Exercised	Unexercised	Exercised	Unexercised	Exercised
Mouse 1
Lamin A/C⁺	11 ± 3	45 ± 1^*	7 ± 5	52 ± 3^*	4 ± 2	32 ± 1^*
Dys⁺ fibers/s	26 ± 13	73 ± 5^*	14 ± 9	61 ± 10^*	10 ± 2	55 ± 11^*
Dys/lamin A/C⁺ fibers	15 ± 61	45 ± 1^*	9 ± 6	47 ± 7^*	5 ± 8	32 ± 22^*
Mouse 2
Lamin A/C⁺	10 ± 8	35 ± 10	15 ± 2	21 ± 14	7 ± 3	37 ± 5^*
Dys⁺ fibers/s	12 ± 5	59 ± 9^*	9 ± 2	48 ± 11^*	18 ± 11	91 ± 32^*
Dys/lamin A/C⁺ fibers	9 ± 3	45 ± 4^*	3 ± 1	27 ± 12^*	9 ± 7	72 ± 18^*
Mouse 3
Lamin A/C⁺	24 ± 11	101 ± 17^*	10 ± 7	70 ± 24^*	17 ± 4	33 ± 13
Dys⁺ fibers/s	16 ± 11	68 ± 11^*	6 ± 2	49 ± 16^*	14 ± 10	46 ± 7^*
Dys/lamin A/C⁺ fibers	8 ± 3	44 ± 12^*	3 ± 1	31 ± 21^*	8 ± 2	29 ± 13^*
Mouse 4
Lamin A/C⁺	19 ± 6	36 ± 19	8 ± 5	24 ± 8	15 ± 7	53 ± 11^*
Dys⁺ fibers/s	10 ± 6	61 ± 21^*	4 ± 3	41 ± 13^*	9 ± 8	57 ± 31^*
Dys/lamin A/C⁺ fibers	7 ± 4	51 ± 15^*	1 ± 2	35 ± 20^*	2 ± 1	31 ± 16^*
Mouse 5
Lamin A/C⁺	18 ± 9	81 ± 21^*	10 ± 4	72 ± 12^*	11 ± 4	43 ± 23^*
Dys⁺ fibers/s	20 ± 11	89 ± 22^*	9 ± 1	53 ± 12^*	14 ± 11	61 ± 15^*
Dys/lamin A/C⁺ fibers	7 ± 3	67 ± 19^*	5 ± 3	26 ± 8^*	5 ± 3	37 ± 25^*

	Quadriceps			Soleus
Positive myofibers	Unexercised	Exercised	Unexercised	Exercised	Unexercised	Exercised
Mouse 1
Lamin A/C⁺	11 ± 3	45 ± 1^*	7 ± 5	52 ± 3^*	4 ± 2	32 ± 1^*
Dys⁺ fibers/s	26 ± 13	73 ± 5^*	14 ± 9	61 ± 10^*	10 ± 2	55 ± 11^*
Dys/lamin A/C⁺ fibers	15 ± 61	45 ± 1^*	9 ± 6	47 ± 7^*	5 ± 8	32 ± 22^*
Mouse 2
Lamin A/C⁺	10 ± 8	35 ± 10	15 ± 2	21 ± 14	7 ± 3	37 ± 5^*
Dys⁺ fibers/s	12 ± 5	59 ± 9^*	9 ± 2	48 ± 11^*	18 ± 11	91 ± 32^*
Dys/lamin A/C⁺ fibers	9 ± 3	45 ± 4^*	3 ± 1	27 ± 12^*	9 ± 7	72 ± 18^*
Mouse 3
Lamin A/C⁺	24 ± 11	101 ± 17^*	10 ± 7	70 ± 24^*	17 ± 4	33 ± 13
Dys⁺ fibers/s	16 ± 11	68 ± 11^*	6 ± 2	49 ± 16^*	14 ± 10	46 ± 7^*
Dys/lamin A/C⁺ fibers	8 ± 3	44 ± 12^*	3 ± 1	31 ± 21^*	8 ± 2	29 ± 13^*
Mouse 4
Lamin A/C⁺	19 ± 6	36 ± 19	8 ± 5	24 ± 8	15 ± 7	53 ± 11^*
Dys⁺ fibers/s	10 ± 6	61 ± 21^*	4 ± 3	41 ± 13^*	9 ± 8	57 ± 31^*
Dys/lamin A/C⁺ fibers	7 ± 4	51 ± 15^*	1 ± 2	35 ± 20^*	2 ± 1	31 ± 16^*
Mouse 5
Lamin A/C⁺	18 ± 9	81 ± 21^*	10 ± 4	72 ± 12^*	11 ± 4	43 ± 23^*
Dys⁺ fibers/s	20 ± 11	89 ± 22^*	9 ± 1	53 ± 12^*	14 ± 11	61 ± 15^*
Dys/lamin A/C⁺ fibers	7 ± 3	67 ± 19^*	5 ± 3	26 ± 8^*	5 ± 3	37 ± 25^*

Results are expressed as number of human lamin A/C-, Dys-, and Dys/lamin A/C-positive cells per section of muscle tissue (± SD) in a longitudinal dimension of approximately 600 μm

Dys indicates dystrophin

P < .01

View Large

This Feature Is Available To Subscribers Only