Histopathologic changes of intestine allografts
. | . | . | Allograft histopathology . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | Intestine . | . | MLNs . | . | . | ||||
| Transplant . | No. of recipients . | Blood chimerism, day 150, % . | No. of apoptosis per 10 crypts . | No. of PPs per section . | No. of lymphoid nodules per section . | Fibrosis grade . | Arteritis grade . | ||||
| Normal intestine | 4 | NA | 0.5 ± 0.6 | 0.30 ± 0.50 | 1.65 ± 0.42 | 0 | 0 | ||||
| Intestine alone | 10 | 0 | 2.0 ± 1.1 | 0.03 ± 0.06 | 0.56 ± 0.50 | 1.00 ± 1.07 | 0.20 ± 0.42 | ||||
| Intestine and BM | 12 | 4.2 ± 3.8* | 1.2 ± 0.5 | 0.28 ± 0.21* | 1.24 ± 0.47 | 0* | 0* | ||||
| Irradiated intestine alone | 5 | 0 | 1.8 ± 0.8 | 0.02 ± 0.02 | 0.48 ± 0.32 | 1.80 ± 0.83 | 0.20 ± 0.45 | ||||
| Intestine from ALS-pretreated donor alone | 7 | 0 | 2.0 ± 1.2 | 0.02 ± 0.05 | 0.84 ± 0.46 | 0.86 ± 0.70 | 0.14 ± 0.24 | ||||
| Irradiated intestine and BM | 8 | 1.9 ± 1.0* | 1.3 ± 0.8 | 0.19 ± 0.16* | 1.00 ± 0.36 | 0* | 0* | ||||
| Intestine from ALS-pretreated donor and BM | 11 | 5.0 ± 3.0* | 2.1 ± 0.5 | 0.20 ± 0.14* | 1.12 ± 0.58 | 0* | 0* | ||||
. | . | . | Allograft histopathology . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | Intestine . | . | MLNs . | . | . | ||||
| Transplant . | No. of recipients . | Blood chimerism, day 150, % . | No. of apoptosis per 10 crypts . | No. of PPs per section . | No. of lymphoid nodules per section . | Fibrosis grade . | Arteritis grade . | ||||
| Normal intestine | 4 | NA | 0.5 ± 0.6 | 0.30 ± 0.50 | 1.65 ± 0.42 | 0 | 0 | ||||
| Intestine alone | 10 | 0 | 2.0 ± 1.1 | 0.03 ± 0.06 | 0.56 ± 0.50 | 1.00 ± 1.07 | 0.20 ± 0.42 | ||||
| Intestine and BM | 12 | 4.2 ± 3.8* | 1.2 ± 0.5 | 0.28 ± 0.21* | 1.24 ± 0.47 | 0* | 0* | ||||
| Irradiated intestine alone | 5 | 0 | 1.8 ± 0.8 | 0.02 ± 0.02 | 0.48 ± 0.32 | 1.80 ± 0.83 | 0.20 ± 0.45 | ||||
| Intestine from ALS-pretreated donor alone | 7 | 0 | 2.0 ± 1.2 | 0.02 ± 0.05 | 0.84 ± 0.46 | 0.86 ± 0.70 | 0.14 ± 0.24 | ||||
| Irradiated intestine and BM | 8 | 1.9 ± 1.0* | 1.3 ± 0.8 | 0.19 ± 0.16* | 1.00 ± 0.36 | 0* | 0* | ||||
| Intestine from ALS-pretreated donor and BM | 11 | 5.0 ± 3.0* | 2.1 ± 0.5 | 0.20 ± 0.14* | 1.12 ± 0.58 | 0* | 0* | ||||
BN-to-LEW SITx under TAC 1.0 mg/kg on days 0-13, 20, and 27 after SITx. Data represent mean ± SD.
NA indicates not applicable.
P < .05 versus intestine alone (1-way ANOVA and Fisher PLSD).