Clinical manifestations of some systemic amyloidoses
Site . | AL . | AA . | ATTR . | AApoAI . | AApoAII . | ALys . | AFib . | AGel . |
|---|---|---|---|---|---|---|---|---|
| Kidney | ++ | ++ | + | ++ | ++ | ++ | ++ | (+) |
| Heart | ++ | (+) | ++ | ++ | + | – | – | (+) |
| PNS | + | – | ++ | + | – | – | – | ++ |
| ANS | + | + | ++ | – | – | – | – | (+) |
| Liver/spleen | + | + | – | ++ | – | ++ | (+) | – |
| GI | + | + | – | – | – | + | – | – |
| CNS | – | – | +* | – | – | – | – | – |
| Skin | + | – | – | + | – | + | – | ++ |
| Eye | – | – | ++ | – | – | – | – | ++ |
| Testis | – | + | – | ++ | – | – | – | – |
Site . | AL . | AA . | ATTR . | AApoAI . | AApoAII . | ALys . | AFib . | AGel . |
|---|---|---|---|---|---|---|---|---|
| Kidney | ++ | ++ | + | ++ | ++ | ++ | ++ | (+) |
| Heart | ++ | (+) | ++ | ++ | + | – | – | (+) |
| PNS | + | – | ++ | + | – | – | – | ++ |
| ANS | + | + | ++ | – | – | – | – | (+) |
| Liver/spleen | + | + | – | ++ | – | ++ | (+) | – |
| GI | + | + | – | – | – | + | – | – |
| CNS | – | – | +* | – | – | – | – | – |
| Skin | + | – | – | + | – | + | – | ++ |
| Eye | – | – | ++ | – | – | – | – | ++ |
| Testis | – | + | – | ++ | – | – | – | – |
AA indicates reactive amyloidosis; ATTR, transthyretin familial amyloidosis; AApoAI, apolipoprotein-AI familial amyloidosis; AApoAII, apolipoprotein-AII familial amyloidosis; ALys, lysozyme familial amyloidosis; AFib, fibrinogen familial amyloidosis; AGel, gelsolin familial amyloidosis; PNS, peripheral nervous system; ANS, autonomic nervous system; GI, gastrointestinal tract; CNS, central nervous system; ++, common; +, observed in a minority of patients; (+), observed rarely; –, not observed
Leptomeningeal