Comparison of human and murine CD38
. | Human . | Murine . |
|---|---|---|
| Structure | 45 kDa, presence of high-molecular-weight forms (p78 and p190), presence of a soluble form | 45 kDa, presence of homodimers, no data on the presence of a soluble form |
| Distribution | Predominantly naive T cells, absent on resting B cells (see below), NK cells, mature dendritic cells | Predominantly splenic and circulating B cells; absent on resting T cells, granulocytes, and immature and mature dendritic cells |
| Function | Activation of T and NK cells, suppression of B lymphopoiesis, rescue from apoptosis of germinal center B cells, cytokine and chemokine production, regulation of adhesion and extravasation | Activation of B cells, cytokine and chemokine production, granulocyte migration to inflammatory sites, dendritic cell trafficking. |
| Ligand | NAD+/NADP+, CD31 | NAD+/NADP+, CD31, unknown p66 and p130 |
| Gene | Chromosome 4, 70 kb; 8 exons; intron 1 ≈ × kb with RARE | Chromosome 5, 43 kb; intron 1 ≈ × kb |
. | Human . | Murine . |
|---|---|---|
| Structure | 45 kDa, presence of high-molecular-weight forms (p78 and p190), presence of a soluble form | 45 kDa, presence of homodimers, no data on the presence of a soluble form |
| Distribution | Predominantly naive T cells, absent on resting B cells (see below), NK cells, mature dendritic cells | Predominantly splenic and circulating B cells; absent on resting T cells, granulocytes, and immature and mature dendritic cells |
| Function | Activation of T and NK cells, suppression of B lymphopoiesis, rescue from apoptosis of germinal center B cells, cytokine and chemokine production, regulation of adhesion and extravasation | Activation of B cells, cytokine and chemokine production, granulocyte migration to inflammatory sites, dendritic cell trafficking. |
| Ligand | NAD+/NADP+, CD31 | NAD+/NADP+, CD31, unknown p66 and p130 |
| Gene | Chromosome 4, 70 kb; 8 exons; intron 1 ≈ × kb with RARE | Chromosome 5, 43 kb; intron 1 ≈ × kb |
The main differences between human and murine CD38 are reviewed in Deaglio and Malavasi.81