Posttransplantation free light chain values impact on hematologic response, organ response, and overall survival (hazard ratios by Cox modeling)
. | Complete hematologic response . | . | Organ response . | . | Overall survival . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| FLC or FLC ratio change . | D 100 . | 1 y . | D 100 . | 1 y . | D 100 . | 1 y . | |||
| No. | 87 | 74 | 93 | 78 | 93 | 75 | |||
| Involved FLC, mg/L (P) | 0.90 (.01) | 0.86 (.02) | 0.98 (.29) | 0.96 (.1) | 1.048 (.003) | 1.048 (.02) | |||
| FLC, normal versus abnormal (P) | 4.92 (< .001) | 5.62 (< .001) | 2.74 (.02) | 2.56 (.04) | 0.13 (.06)* | 0.27 (.1)* | |||
| At least 50% reduction FLC (P) | 2.69 (.09) | 3.04 (.08) | 1.81 (.3) | 6.0 (.009) | 0.42 (.4)† | 0.87 (.9)† | |||
| At least 90% reduction FLC (P) | 3.47 (.01) | 2.91 (.04) | 2.10 (.1) | 1.45 (.5) | 0.70 (.6)‡ | 0.96 (> .999)‡ | |||
| FLC ratio, mg/L (P) | 0.98 (.09) | 0.94 (.02) | 1.0 (.6) | 0.98 (.2) | 0.99 (.8) | 1.027 (.07) | |||
| FLC ratio, normal vs abnormal (P) | 2.41 (< .05) | 5.00 (.002) | 0.77 (.5) | 2.51 (.05) | 0.65 (.6) | 0.60 (.5)¶ | |||
. | Complete hematologic response . | . | Organ response . | . | Overall survival . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| FLC or FLC ratio change . | D 100 . | 1 y . | D 100 . | 1 y . | D 100 . | 1 y . | |||
| No. | 87 | 74 | 93 | 78 | 93 | 75 | |||
| Involved FLC, mg/L (P) | 0.90 (.01) | 0.86 (.02) | 0.98 (.29) | 0.96 (.1) | 1.048 (.003) | 1.048 (.02) | |||
| FLC, normal versus abnormal (P) | 4.92 (< .001) | 5.62 (< .001) | 2.74 (.02) | 2.56 (.04) | 0.13 (.06)* | 0.27 (.1)* | |||
| At least 50% reduction FLC (P) | 2.69 (.09) | 3.04 (.08) | 1.81 (.3) | 6.0 (.009) | 0.42 (.4)† | 0.87 (.9)† | |||
| At least 90% reduction FLC (P) | 3.47 (.01) | 2.91 (.04) | 2.10 (.1) | 1.45 (.5) | 0.70 (.6)‡ | 0.96 (> .999)‡ | |||
| FLC ratio, mg/L (P) | 0.98 (.09) | 0.94 (.02) | 1.0 (.6) | 0.98 (.2) | 0.99 (.8) | 1.027 (.07) | |||
| FLC ratio, normal vs abnormal (P) | 2.41 (< .05) | 5.00 (.002) | 0.77 (.5) | 2.51 (.05) | 0.65 (.6) | 0.60 (.5)¶ | |||
At day 100, 44 patients with normal FLC levels versus 49 with abnormal levels; at 1 year, 39 patients with normal FLC levels versus 39 with abnormal levels
At day 100, 74 patients with normal FLC levels had at least 50% reduction versus 19 with less than 50%; at 1 year, 62 patients with normal FLC levels had at least 50% reduction, versus 16 with less than 50%
At day 100, 26 patients with normal FLC levels had at least 90% reduction versus 67 with less than 90%; at 1 year, 23 patients with normal FLC levels had at least 90% reduction versus 55 with less than 90%
At day 100, 48 patients with normal FLC levels had at least normal ratio versus 44 with abnormal levels; at 1 year, 38 had normal ratio versus 37 with abnormal levels