Hematologic responses to 3 different conditional signaling proteins
Response . | F36VFGFR1 . | F36VMpl . | V′ VJak2 . |
---|---|---|---|
In vitro | |||
Sustained expansion in culture | + | + | - |
Expansion of stHSCs | + | - | ND |
Survival of ltHSCs | + | - | ND |
In vivo | |||
Red cells | +++ | ++ | + |
Platelets | +++ | + | - |
Granulocytes/monocytes | +++ | +/- | - |
Response . | F36VFGFR1 . | F36VMpl . | V′ VJak2 . |
---|---|---|---|
In vitro | |||
Sustained expansion in culture | + | + | - |
Expansion of stHSCs | + | - | ND |
Survival of ltHSCs | + | - | ND |
In vivo | |||
Red cells | +++ | ++ | + |
Platelets | +++ | + | - |
Granulocytes/monocytes | +++ | +/- | - |
+ indicates present; -, absent; ND, not done; +++, strongest effect; ++, strong effect; +/-, variable and modest effect.