Table 2.

Hematologic responses to 3 different conditional signaling proteins


Response

F36VFGFR1

F36VMpl

V′ VJak2
In vitro    
    Sustained expansion in culture   +   +   -  
    Expansion of stHSCs   +   -   ND  
    Survival of ltHSCs   +   -   ND  
In vivo    
    Red cells   +++   ++   +  
    Platelets   +++   +   -  
    Granulocytes/monocytes
 
+++
 
+/-
 
-
 

Response

F36VFGFR1

F36VMpl

V′ VJak2
In vitro    
    Sustained expansion in culture   +   +   -  
    Expansion of stHSCs   +   -   ND  
    Survival of ltHSCs   +   -   ND  
In vivo    
    Red cells   +++   ++   +  
    Platelets   +++   +   -  
    Granulocytes/monocytes
 
+++
 
+/-
 
-
 

+ indicates present; -, absent; ND, not done; +++, strongest effect; ++, strong effect; +/-, variable and modest effect.