Comparison of clinical and laboratory data among patients with and without translocations at cytogenetic analysis
Parameter . | With translocations . | Without translocations . | P . |
|---|---|---|---|
| Median age, y (range) | 63 (39-86) | 59 (35-83) | .020* |
| No. male/no. total (% male) | 24/33 (73) | 39/63 (62) | .371† |
| Median time from diagnosis to investigation, mo (range) | 53 (0-228) | 35 (0-324) | .491‡ |
| Disease stage at enrollment, no. patients/no. total (% of patients) | |||
| Binet A | 2/33 (6) | 26/60 (43) | < .001† |
| Binet B | 10/33 (30) | 18/60 (30) | |
| Binet C | 21/33 (64) | 16/60 (27) | |
| Rai 0 | 1/33 (3) | 8/59 (14) | .002† |
| Rai 1 | 2/33 (6) | 13/59 (22) | |
| Rai 2 | 8/33 (24) | 21/59 (35) | |
| Rai 3 | 7/33 (21) | 0/59 (0) | |
| Rai 4 | 15/33 (46) | 17/59 (29) | |
| Median WBC count, × 109/L (range) | 43.4 (5.2-210.0) | 34.7 (5.6-254.0) | .851* |
| Median hemoglobin level, g/dL (range) | 11.5 (8.2-17.0) | 13.5 (7.4-17.2) | .003* |
| Median platelet count, × 109/L (range) | 131 (9-238) | 148 (7-311) | .079* |
| Median lactate dehydrogenase level, IU/L (range) | 238 (126-622) | 192 (128-581) | .112* |
| Median albumin level, g/dL (range) | 3.95 (3.3-5.4) | 4.50 (4.0-5.5) | .061* |
| Median β2-microglobulin level, mg/L (range) | 4.27 (1.4-14.3) | 2.47 (1.1-7.4) | < .001* |
| Median thymidine kinase level, IU/L (range) | 19.2 (4.9-58.5) | 8.8 (2.6-45.0) | .004* |
| High CD38 expression, no. patients/no. total (% of patients) | 9/15 (60) | 4/52 (8) | .003† |
| Lymphocyte doubling time below 12 months, no. patients/no. total (% of patients) | 13/28 (46) | 15/56 (27) | .089† |
| Splenomegaly, no. patients/no. total (% of patients) | 20/26 (77) | 31/55 (56) | .089† |
| Peripheral lymphadenopathy, no. patients/no. total (% of patients) | 20/25 (80) | 42/56 (75) | .779† |
| Median time from diagnosis to first treatment, mo (range) | 24 (17-31) | 110 (74-138) | < .001‡ |
| Previous treatment with chlorambucil, no. patients/no. total (% of patients) | 15/21 (71) | 16/17 (94) | .104† |
Parameter . | With translocations . | Without translocations . | P . |
|---|---|---|---|
| Median age, y (range) | 63 (39-86) | 59 (35-83) | .020* |
| No. male/no. total (% male) | 24/33 (73) | 39/63 (62) | .371† |
| Median time from diagnosis to investigation, mo (range) | 53 (0-228) | 35 (0-324) | .491‡ |
| Disease stage at enrollment, no. patients/no. total (% of patients) | |||
| Binet A | 2/33 (6) | 26/60 (43) | < .001† |
| Binet B | 10/33 (30) | 18/60 (30) | |
| Binet C | 21/33 (64) | 16/60 (27) | |
| Rai 0 | 1/33 (3) | 8/59 (14) | .002† |
| Rai 1 | 2/33 (6) | 13/59 (22) | |
| Rai 2 | 8/33 (24) | 21/59 (35) | |
| Rai 3 | 7/33 (21) | 0/59 (0) | |
| Rai 4 | 15/33 (46) | 17/59 (29) | |
| Median WBC count, × 109/L (range) | 43.4 (5.2-210.0) | 34.7 (5.6-254.0) | .851* |
| Median hemoglobin level, g/dL (range) | 11.5 (8.2-17.0) | 13.5 (7.4-17.2) | .003* |
| Median platelet count, × 109/L (range) | 131 (9-238) | 148 (7-311) | .079* |
| Median lactate dehydrogenase level, IU/L (range) | 238 (126-622) | 192 (128-581) | .112* |
| Median albumin level, g/dL (range) | 3.95 (3.3-5.4) | 4.50 (4.0-5.5) | .061* |
| Median β2-microglobulin level, mg/L (range) | 4.27 (1.4-14.3) | 2.47 (1.1-7.4) | < .001* |
| Median thymidine kinase level, IU/L (range) | 19.2 (4.9-58.5) | 8.8 (2.6-45.0) | .004* |
| High CD38 expression, no. patients/no. total (% of patients) | 9/15 (60) | 4/52 (8) | .003† |
| Lymphocyte doubling time below 12 months, no. patients/no. total (% of patients) | 13/28 (46) | 15/56 (27) | .089† |
| Splenomegaly, no. patients/no. total (% of patients) | 20/26 (77) | 31/55 (56) | .089† |
| Peripheral lymphadenopathy, no. patients/no. total (% of patients) | 20/25 (80) | 42/56 (75) | .779† |
| Median time from diagnosis to first treatment, mo (range) | 24 (17-31) | 110 (74-138) | < .001‡ |
| Previous treatment with chlorambucil, no. patients/no. total (% of patients) | 15/21 (71) | 16/17 (94) | .104† |
P values for Binet A-C and Rai 0-4 are calculated collectively.
To convert hemoglobin from grams per deciliter to grams per liter, multiply grams per deciliter by 10.
To convert albumin from grams per deciliter to grams per liter, multiply grams per deciliter by 10.
To convert β2-microglobulin from milligrams per liter to nanomoles per liter, multiply milligrams per liter by 85.
P values according to Mann-Whitney U test for continuous variables.
P values according to ϰ2 for categorical variables.
P values according to log rank test.