Proposed criteria for diagnosis and staging of scleromyxedema
Diagnosis |
| Histologic presence of dermal mucin deposit with increased collagen deposition and fibroblast proliferation and presence of a serum monoclonal gammopathy |
| Staging |
| Clinical stage I: limited cutaneous papular mucinosis |
| Clinical stage II: generalized cutaneous mucinosis and/or extracutaneous manifestation(s) |
| Clinical stage III: generalized cutaneous mucinosis and/or extracutaneous manifestation(s) and disease-related Karnofsky PS < 50% |
Diagnosis |
| Histologic presence of dermal mucin deposit with increased collagen deposition and fibroblast proliferation and presence of a serum monoclonal gammopathy |
| Staging |
| Clinical stage I: limited cutaneous papular mucinosis |
| Clinical stage II: generalized cutaneous mucinosis and/or extracutaneous manifestation(s) |
| Clinical stage III: generalized cutaneous mucinosis and/or extracutaneous manifestation(s) and disease-related Karnofsky PS < 50% |