Different rationale for immunotherapy for PTLD in recipients of stem cell and solid organ transplants
Stem cell transplantations . | Solid organ transplantations . |
|---|---|
| Healthy donor available to provide blood sample | Donor not generally available |
| Tumor usually arises in donor cell | Tumor usually arises in recipient cell |
| Donor and recipient share hemopoietic system (HLA identical) | Donor and recipient generally HLA mismatched |
| Conclusion: donor CTLs can be used | Conclusion: donor CTLs cannot be used |
Stem cell transplantations . | Solid organ transplantations . |
|---|---|
| Healthy donor available to provide blood sample | Donor not generally available |
| Tumor usually arises in donor cell | Tumor usually arises in recipient cell |
| Donor and recipient share hemopoietic system (HLA identical) | Donor and recipient generally HLA mismatched |
| Conclusion: donor CTLs can be used | Conclusion: donor CTLs cannot be used |
CTLs indicate cytotoxic T lymphocytes.