EBV-associated diseases of lymphoid origin
Disease . | Population at high risk . | EBV association . |
|---|---|---|
| Infectious mononucleosis | Young adults in the West | Majority |
| X-linked lymphoproliferative disease (XLP) | Males with mutations in the XLP gene | Majority |
| B lymphoproliferative disease (BLPD) | Posttransplantation LP | < 90% |
| HIV-infected individuals | ||
| Primary central nervous system lymphoma | 100% | |
| Peripheral lymphoma | < 80% | |
| Burkitt lymphoma (BL) | African children (endemic) | 97%-100% |
| HIV-infected individuals/sporadic | < 25% | |
| Hodgkin disease (HD) | Children in developing countries | 40%-80%, depending on type |
| Young adults in high socioeconomic groups with history of IM | 40%-80%, depending on type | |
| Nasal T-cell lymphoma | Asian populations | 100% |
| NK lymphoma | Individuals with chronic active EBV | 10%-100%, depending on type |
| HIV-infected individuals | 10%-100%, depending on type | |
| Primary effusion lymphoma | HIV-infected individuals | 70%-80%; 100%, contain KSHV DNA |
Disease . | Population at high risk . | EBV association . |
|---|---|---|
| Infectious mononucleosis | Young adults in the West | Majority |
| X-linked lymphoproliferative disease (XLP) | Males with mutations in the XLP gene | Majority |
| B lymphoproliferative disease (BLPD) | Posttransplantation LP | < 90% |
| HIV-infected individuals | ||
| Primary central nervous system lymphoma | 100% | |
| Peripheral lymphoma | < 80% | |
| Burkitt lymphoma (BL) | African children (endemic) | 97%-100% |
| HIV-infected individuals/sporadic | < 25% | |
| Hodgkin disease (HD) | Children in developing countries | 40%-80%, depending on type |
| Young adults in high socioeconomic groups with history of IM | 40%-80%, depending on type | |
| Nasal T-cell lymphoma | Asian populations | 100% |
| NK lymphoma | Individuals with chronic active EBV | 10%-100%, depending on type |
| HIV-infected individuals | 10%-100%, depending on type | |
| Primary effusion lymphoma | HIV-infected individuals | 70%-80%; 100%, contain KSHV DNA |
NK indicates natural killer; KSHV, Kaposi sarcoma–associated herpesvirus.