Table 1.

Incidence of hematopoietic neoplasms by subtype and ICD-O-3 codes, 12 SEER registries, 1992-2001

Hematopoietic neoplasm subtype
ICD-O-3 codes*†
No.
Rate‡
Lymphoid neoplasms, total  –   114 548   33.65  
B-cell lymphoid neoplasms, total  9590-9591(B), 9596(B), 9670-9671, 9673, 9675(B), 9678-9680, 9684, 9687, 9689-9691, 9695, 9698-9699, 9727(B), 9728, 9731-9734, 9761, 9764, 9820(B), 9823, 9826, 9832(B), 9833, 9835(B), 9836, 9940, 9970(B)   87 666   26.13  
   DLBCL   9675(B), 9678-9680, 9684   24 246   7.14  
   Marginal zone lymphoma   9689, 9699   3247   0.97  
   Follicular lymphoma   9690-9691, 9695, 9698   10 705   3.18  
   CLL/SLL   9670, 9823   16 984   5.17  
   Mantle cell lymphoma   9673   1691   0.51  
   Burkitt lymphoma/leukemia   9687, 9826   1102   0.30  
   Plasma cell neoplasms   9731-9734   18 644   5.66  
      Multiple myeloma   9732   17 407   5.29  
      Plasma cell leukemia   9733   107   0.03  
      Plasmacytoma   9731, 9734   1130   0.34  
   Hairy cell leukemia   9940   1116   0.33  
   Lymphoplasmacytic lymphoma   9671   911   0.27  
   Waldenstrom macroglobulinemia   9761   1144   0.35  
   B-cell lymphoid neoplasms, NOS   9590-9591(B), 9596(B), 9764, 9820(B), 9970(B)   4872   1.45  
T/NK-cell lymphoid neoplasms, total  9590-9591(T/NK), 9596(T/NK), 9675(T/NK), 9700-9702, 9705, 9708-9709, 9714, 9716-9719, 9727(T/NK), 9729, 9820(T/NK), 9827, 9831, 9832(T/NK), 9834, 9835(T/NK), 9837, 9948, 9970(T/NK)   6228   1.79  
   Mycosis fungoides/Sézary syndrome   9700-9701   1773   0.52  
   Peripheral T-cell lymphoma   9675(T/NK), 9702, 9705, 9708, 9714, 9716, 9827   2071   0.60  
      Angioimmunoblastic lymphoma   9705   176   0.05  
      Anaplastic large-cell lymphoma   9714   864   0.25  
      Peripheral T-cell lymphoma, NOS   9675(T/NK), 9702, 9708, 9716, 9827   1031   0.30  
   T/NK-cell lymphoid neoplasms, NOS   9590-9591(T/NK), 9596(T/NK), 9709, 9717-9719, 9820(T/NK), 9831, 9948, 9970(T/NK)   1501   0.44  
Lymphoblastic leukemia/lymphoma§  9727-9729, 9835-9837   6127   1.61  
   B-cell lymphoblastic leukemia/lymphoma   9727(B), 9728, 9835(B), 9836   2907   0.76  
   T-cell lymphoblastic leukemia/lymphoma   9727(T/NK), 9729, 9835(T/NK), 9837   852   0.22  
   Unknown type lymphoblastic leukemia/lymphoma   9727, 9835(unknown)   2368   0.63  
Prolymphocytic leukemia  9832-9834   237   0.07  
Hodgkin lymphoma  9650-9655, 9659, 9661-9665, 9667   10 042   2.67  
   Classical Hodgkin lymphoma   9650-9655, 9661-9665, 9667   9734   2.59  
      Nodular sclerosis   9663-9665, 9667   6270   1.63  
      Mixed cellularity/lymphocyte depleted   9652-9655   1906   0.53  
      Classical Hodgkin lymphoma, NOS   9650-9651, 9661-9662   1558   0.43  
   Nodular lymphocyte predominant Hodgkin lymphoma   9659   308   0.08  
Unknown type lymphoid neoplasms  9590-9591(unknown), 9596(unknown), 9675(unknown), 9820(unknown), 9970(unknown)   8135   2.40  
Nonlymphoid hematopoietic neoplasms, total  –   22 437   6.63  
   Chronic myeloproliferative diseases∥  9950, 9960-9964, 9975    
   Myelodysplastic syndromes∥  9980, 9982-9987, 9989    
   Myeloid leukemias   9840, 9860-9861, 9863, 9866-9867, 9870-9876, 9891, 9895-9897, 9910, 9920, 9930-9931, 9945-9946   19 640   5.78  
      Acute myeloid leukemias   9840, 9861, 9866-9867, 9870-9874, 9891, 9895-9897, 9910, 9920, 9930-9931   13 358   3.93  
      Chronic myeloid leukemias   9863, 9875-9876, 9945-9946   5863   1.72  
      Myeloid leukemias, NOS   9860   419   0.13  
   Leukemias, NOS  9800-9801, 9805   2597   0.79  
   Mast cell neoplasms   9740-9742   65   0.02  
   Histiocytic and dendritic cell neoplasms   9750-9758   122   0.03  
   Other hematopoietic diseases  9760, 9762, 9765-9769   13   0.00  
Hematopoietic neoplasms total
 		 –
 		 136 985
 		 40.28
 
Hematopoietic neoplasm subtype
ICD-O-3 codes*†
No.
Rate‡
Lymphoid neoplasms, total  –   114 548   33.65  
B-cell lymphoid neoplasms, total  9590-9591(B), 9596(B), 9670-9671, 9673, 9675(B), 9678-9680, 9684, 9687, 9689-9691, 9695, 9698-9699, 9727(B), 9728, 9731-9734, 9761, 9764, 9820(B), 9823, 9826, 9832(B), 9833, 9835(B), 9836, 9940, 9970(B)   87 666   26.13  
   DLBCL   9675(B), 9678-9680, 9684   24 246   7.14  
   Marginal zone lymphoma   9689, 9699   3247   0.97  
   Follicular lymphoma   9690-9691, 9695, 9698   10 705   3.18  
   CLL/SLL   9670, 9823   16 984   5.17  
   Mantle cell lymphoma   9673   1691   0.51  
   Burkitt lymphoma/leukemia   9687, 9826   1102   0.30  
   Plasma cell neoplasms   9731-9734   18 644   5.66  
      Multiple myeloma   9732   17 407   5.29  
      Plasma cell leukemia   9733   107   0.03  
      Plasmacytoma   9731, 9734   1130   0.34  
   Hairy cell leukemia   9940   1116   0.33  
   Lymphoplasmacytic lymphoma   9671   911   0.27  
   Waldenstrom macroglobulinemia   9761   1144   0.35  
   B-cell lymphoid neoplasms, NOS   9590-9591(B), 9596(B), 9764, 9820(B), 9970(B)   4872   1.45  
T/NK-cell lymphoid neoplasms, total  9590-9591(T/NK), 9596(T/NK), 9675(T/NK), 9700-9702, 9705, 9708-9709, 9714, 9716-9719, 9727(T/NK), 9729, 9820(T/NK), 9827, 9831, 9832(T/NK), 9834, 9835(T/NK), 9837, 9948, 9970(T/NK)   6228   1.79  
   Mycosis fungoides/Sézary syndrome   9700-9701   1773   0.52  
   Peripheral T-cell lymphoma   9675(T/NK), 9702, 9705, 9708, 9714, 9716, 9827   2071   0.60  
      Angioimmunoblastic lymphoma   9705   176   0.05  
      Anaplastic large-cell lymphoma   9714   864   0.25  
      Peripheral T-cell lymphoma, NOS   9675(T/NK), 9702, 9708, 9716, 9827   1031   0.30  
   T/NK-cell lymphoid neoplasms, NOS   9590-9591(T/NK), 9596(T/NK), 9709, 9717-9719, 9820(T/NK), 9831, 9948, 9970(T/NK)   1501   0.44  
Lymphoblastic leukemia/lymphoma§  9727-9729, 9835-9837   6127   1.61  
   B-cell lymphoblastic leukemia/lymphoma   9727(B), 9728, 9835(B), 9836   2907   0.76  
   T-cell lymphoblastic leukemia/lymphoma   9727(T/NK), 9729, 9835(T/NK), 9837   852   0.22  
   Unknown type lymphoblastic leukemia/lymphoma   9727, 9835(unknown)   2368   0.63  
Prolymphocytic leukemia  9832-9834   237   0.07  
Hodgkin lymphoma  9650-9655, 9659, 9661-9665, 9667   10 042   2.67  
   Classical Hodgkin lymphoma   9650-9655, 9661-9665, 9667   9734   2.59  
      Nodular sclerosis   9663-9665, 9667   6270   1.63  
      Mixed cellularity/lymphocyte depleted   9652-9655   1906   0.53  
      Classical Hodgkin lymphoma, NOS   9650-9651, 9661-9662   1558   0.43  
   Nodular lymphocyte predominant Hodgkin lymphoma   9659   308   0.08  
Unknown type lymphoid neoplasms  9590-9591(unknown), 9596(unknown), 9675(unknown), 9820(unknown), 9970(unknown)   8135   2.40  
Nonlymphoid hematopoietic neoplasms, total  –   22 437   6.63  
   Chronic myeloproliferative diseases∥  9950, 9960-9964, 9975    
   Myelodysplastic syndromes∥  9980, 9982-9987, 9989    
   Myeloid leukemias   9840, 9860-9861, 9863, 9866-9867, 9870-9876, 9891, 9895-9897, 9910, 9920, 9930-9931, 9945-9946   19 640   5.78  
      Acute myeloid leukemias   9840, 9861, 9866-9867, 9870-9874, 9891, 9895-9897, 9910, 9920, 9930-9931   13 358   3.93  
      Chronic myeloid leukemias   9863, 9875-9876, 9945-9946   5863   1.72  
      Myeloid leukemias, NOS   9860   419   0.13  
   Leukemias, NOS  9800-9801, 9805   2597   0.79  
   Mast cell neoplasms   9740-9742   65   0.02  
   Histiocytic and dendritic cell neoplasms   9750-9758   122   0.03  
   Other hematopoietic diseases  9760, 9762, 9765-9769   13   0.00  
Hematopoietic neoplasms total
 		 –
 		 136 985
 		 40.28
 

ICD-O-3 indicates International Classification of Diseases for Oncology, Third Edition; SEER, Surveillance, Epidemiology, and End Results; DLBCL, diffuse large B-cell lymphoma; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; NOS, not otherwise specified; NK, natural killer (cell).

*

Data on histologic type and primary site were coded to ICD-O-2 (44) for cases diagnosed between 1992 and 2000 or ICD-O-3 (45) for cases diagnosed in 2001. SEER used a conversion algorithm to translate cases coded using ICD-O-2 to ICD-O-3 (40)

†

Codes followed by parentheses indicate that immunophenotyping data (B-cell, T/NK-cell, or unknown) were used to assign cases to that lymphoid neoplasm subtype

‡

All incidence rates are age adjusted to the 2000 United States population and expressed per 100 000 person-years

§

Also known as acute lymphoblastic leukemia (ALL)

∥

Chronic myeloproliferative diseases and myelodysplastic syndromes, now classified as malignant in ICD-O-3, were classified as uncertain behavior in ICD-O-2 and thus were not reportable to SEER until 2001. In 2001, 634 cases (1.77 cases per 100 000 persons) of chronic myeloproliferative diseases and 1024 cases (2.91 cases per 100 000 persons) of myelodysplastic syndromes were diagnosed. These disease entities were excluded from our analysis

Lymphoid versus myeloid origin not determined

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