Second cancers and late nonmalignant toxicities
. | . | . | Patients randomized for consolidation, no. . | . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | No. events observed . | Patients not randomized for consolidation, no. . | MOPP/ABV ×8 . | ABVPP ×8 . | MOPP/ABV + RT . | ABVPP ×6 + RT . | Related deaths, no. . | |||
| Second cancers | 38 | 10 | 8 | 6 | 8 | 6 | 24 | |||
| Solid tumors | 23 | 7 | 5 | 2 | 5 | 4 | 15 | |||
| Lung | 9 | 3 | 2 | 0 | 1 | 3 | 8 | |||
| Gastrointestinal tract | 4 | 2 | 1 | 0 | 1 | 0 | 2 | |||
| Liver, pancreas | 3 | 1 | 0 | 0 | 2 | 0 | 2 | |||
| Head and neck | 3 | 1 | 1 | 1 | 0 | 0 | 2 | |||
| Breast | 1 | 0 | 0 | 0 | 0 | 1 | 0 | |||
| Other | 1 | 0 | 1 | 0 | 0 | 0 | 0 | |||
| Cutaneous | 2 | 0 | 0 | 1 | 1 | 0 | 1 | |||
| AML - MDS | 10 | 3 | 2 | 2 | 1 | 2 | 5 | |||
| NHL | 5 | 0 | 1 | 2 | 2 | 0 | 4 | |||
| Nonmalignant toxicities | 102 | 17 | 16 | 20 | 29 | 20 | 6 | |||
| Infectious | 13 | 1 | 2 | 3 | 5 | 2 | 2 | |||
| Cardiovascular | 15 | 3 | 3 | 5 | 2 | 2 | 1 | |||
| Respiratory | 8 | 1 | 4 | 0 | 2 | 1 | 1 | |||
| Hypothyroidism | 21 | 3 | 1 | 2 | 9 | 6 | 0 | |||
| Hyperthyreosis | 5 | 0 | 0 | 1 | 4 | 0 | 0 | |||
| Female gonadal dysfunction | 12 | 3 | 0 | 5 | 3 | 1 | 0 | |||
| Male sterility | 13 | 2 | 1 | 3 | 4 | 3 | 0 | |||
| Prolonged cytopenia | 3 | 1 | 1 | 0 | 0 | 1 | 0 | |||
| Peripheral neuropathy | 1 | 0 | 0 | 0 | 0 | 1 | 0 | |||
| Psychologic | 2 | 1 | 1 | 0 | 0 | 0 | 1 | |||
| Femoral osteonecrosis | 5 | 1 | 1 | 1 | 0 | 2 | 0 | |||
| Miscellaneous | 4 | 1 | 2 | 0 | 0 | 1 | 1 | |||
. | . | . | Patients randomized for consolidation, no. . | . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | No. events observed . | Patients not randomized for consolidation, no. . | MOPP/ABV ×8 . | ABVPP ×8 . | MOPP/ABV + RT . | ABVPP ×6 + RT . | Related deaths, no. . | |||
| Second cancers | 38 | 10 | 8 | 6 | 8 | 6 | 24 | |||
| Solid tumors | 23 | 7 | 5 | 2 | 5 | 4 | 15 | |||
| Lung | 9 | 3 | 2 | 0 | 1 | 3 | 8 | |||
| Gastrointestinal tract | 4 | 2 | 1 | 0 | 1 | 0 | 2 | |||
| Liver, pancreas | 3 | 1 | 0 | 0 | 2 | 0 | 2 | |||
| Head and neck | 3 | 1 | 1 | 1 | 0 | 0 | 2 | |||
| Breast | 1 | 0 | 0 | 0 | 0 | 1 | 0 | |||
| Other | 1 | 0 | 1 | 0 | 0 | 0 | 0 | |||
| Cutaneous | 2 | 0 | 0 | 1 | 1 | 0 | 1 | |||
| AML - MDS | 10 | 3 | 2 | 2 | 1 | 2 | 5 | |||
| NHL | 5 | 0 | 1 | 2 | 2 | 0 | 4 | |||
| Nonmalignant toxicities | 102 | 17 | 16 | 20 | 29 | 20 | 6 | |||
| Infectious | 13 | 1 | 2 | 3 | 5 | 2 | 2 | |||
| Cardiovascular | 15 | 3 | 3 | 5 | 2 | 2 | 1 | |||
| Respiratory | 8 | 1 | 4 | 0 | 2 | 1 | 1 | |||
| Hypothyroidism | 21 | 3 | 1 | 2 | 9 | 6 | 0 | |||
| Hyperthyreosis | 5 | 0 | 0 | 1 | 4 | 0 | 0 | |||
| Female gonadal dysfunction | 12 | 3 | 0 | 5 | 3 | 1 | 0 | |||
| Male sterility | 13 | 2 | 1 | 3 | 4 | 3 | 0 | |||
| Prolonged cytopenia | 3 | 1 | 1 | 0 | 0 | 1 | 0 | |||
| Peripheral neuropathy | 1 | 0 | 0 | 0 | 0 | 1 | 0 | |||
| Psychologic | 2 | 1 | 1 | 0 | 0 | 0 | 1 | |||
| Femoral osteonecrosis | 5 | 1 | 1 | 1 | 0 | 2 | 0 | |||
| Miscellaneous | 4 | 1 | 2 | 0 | 0 | 1 | 1 | |||