Table 2. Immunostaining of normal... | American Society of Hematology

Table 2.

Immunostaining of normal hematopoietic tissues for transmembrane adaptor proteins

	LAT	LIME	TRIM	NTAL	PAG	SIT
Tonsil/lymph node
Lymphoid follicles
Germinal centers	Neg	Neg	Neg	Pos	Pos	Neg to weak
Mantle zones	Neg	Neg	Neg	Pos	Neg	Neg to weak
Monocytoid B cells^*	Neg	Neg	Neg	Pos	Pos	Neg
Plasma cells	Neg	Pos	Neg	Pos	Pos	Pos
T cells	Pos	Pos	Pos	Neg	Pos	Pos
Spleen
B-cell areas
Marginal zones	Neg	Neg	Neg	Pos	Pos	Neg to weak
Mantle zones	Neg	Neg	Neg	Pos	Pos	Pos
T cells	Pos	Pos	Pos	Neg	Pos	Pos
Red pulp	Scattered cells	Neg	Neg	Neg	Pos†	Neg
Thymus
Cortex	Pos	Pos	Pos	Neg	Weak	Pos
Medulla	Pos	Pos	Pos	Rare cells	Pos	Pos
Bone marrow
Erythroid	Neg	Neg	Neg	Neg	Neg	Neg
Granulocytic	Neg	Neg	Neg	Neg	Pos	Neg
Megakaryocytes	Pos	Neg	Neg	Neg to Pos‡	Neg	Neg
Plasma cells	Neg	Pos	Neg/Rare pos	Pos	Pos	Pos

	LAT	LIME	TRIM	NTAL	PAG	SIT
Tonsil/lymph node
Lymphoid follicles
Germinal centers	Neg	Neg	Neg	Pos	Pos	Neg to weak
Mantle zones	Neg	Neg	Neg	Pos	Neg	Neg to weak
Monocytoid B cells^*	Neg	Neg	Neg	Pos	Pos	Neg
Plasma cells	Neg	Pos	Neg	Pos	Pos	Pos
T cells	Pos	Pos	Pos	Neg	Pos	Pos
Spleen
B-cell areas
Marginal zones	Neg	Neg	Neg	Pos	Pos	Neg to weak
Mantle zones	Neg	Neg	Neg	Pos	Pos	Pos
T cells	Pos	Pos	Pos	Neg	Pos	Pos
Red pulp	Scattered cells	Neg	Neg	Neg	Pos†	Neg
Thymus
Cortex	Pos	Pos	Pos	Neg	Weak	Pos
Medulla	Pos	Pos	Pos	Rare cells	Pos	Pos
Bone marrow
Erythroid	Neg	Neg	Neg	Neg	Neg	Neg
Granulocytic	Neg	Neg	Neg	Neg	Pos	Neg
Megakaryocytes	Pos	Neg	Neg	Neg to Pos‡	Neg	Neg
Plasma cells	Neg	Pos	Neg/Rare pos	Pos	Pos	Pos

Neg indicates negative; pos, positive.

This cell population was identified in lymph nodes reacting to toxoplasmosis

In the red pulp, PAG stained sinusoidal macrophages weakly

NTAL was heterogeneously expressed in megakaryocytes that showed either negative or weak to moderate positivity