HCV infection history of the recovered or chronically HCV-infected chimpanzees included in this study
. | HCV infection, HCV genotype/treatment . | . | . | . | ||
|---|---|---|---|---|---|---|
| Chimpanzee . | Primary infection . | First HCV rechallenge . | Second rechallenge . | Reference . | ||
| HCV-recovered chimpanzees | ||||||
| Ch1552 | 1a/IH, cleared after 16 wk | 1a/IV, cleared after 4 wk | 1a/IV, sterilizing immunity | Nascimbeni et al22 ; Major et al23 | ||
| Ch4×0186 | 1a/IV, cleared after 9 wk | 1a/IV, cleared after 6 wk | 1b/IV, sterilizing immunity | Nascimbeni et al22 ; Major et al23 | ||
| Ch4×0132 | 1b/IH, cleared after 8 wk | 1b/IV, cleared after 10 wk | NA | Thomson et al31,32 | ||
| Ch1605 | 1a/IV, cleared after 12 wk | 1a/IV, cleared after 3 wk | NA | Nascimbeni et al22 ; Major et al23 | ||
| Ch4×0190 | 1b/IV, cleared after 10 wk | NA | NA | Thomson et al31,32 | ||
| Ch4×0355 | IV, recovered after 9 wk | NA | NA | NA | ||
| Ch6455 | 1a/IV, recovered after 14 wk | NA | NA | Major et al30 | ||
| Ch6461 | 1a/IV, recovered after 18 wk | NA | NA | Major et al30 | ||
| Persistently HCV-infected chimpanzees | ||||||
| Ch6411 | 1a/IV | NA | NA | Major et al30 | ||
| Ch6412 | 1a/IV | NA | NA | Major et al30 | ||
| Ch6475 | 1a/IV | NA | NA | Major et al30 | ||
| Ch1629 | 1a/IV | NA | NA | Major et al30 | ||
| Ch1535 | 1a/IH | NA | NA | Kolykhalov et al33 | ||
| Ch1536 | 1a/IH | NA | NA | Kolykhalov et al33 | ||
. | HCV infection, HCV genotype/treatment . | . | . | . | ||
|---|---|---|---|---|---|---|
| Chimpanzee . | Primary infection . | First HCV rechallenge . | Second rechallenge . | Reference . | ||
| HCV-recovered chimpanzees | ||||||
| Ch1552 | 1a/IH, cleared after 16 wk | 1a/IV, cleared after 4 wk | 1a/IV, sterilizing immunity | Nascimbeni et al22 ; Major et al23 | ||
| Ch4×0186 | 1a/IV, cleared after 9 wk | 1a/IV, cleared after 6 wk | 1b/IV, sterilizing immunity | Nascimbeni et al22 ; Major et al23 | ||
| Ch4×0132 | 1b/IH, cleared after 8 wk | 1b/IV, cleared after 10 wk | NA | Thomson et al31,32 | ||
| Ch1605 | 1a/IV, cleared after 12 wk | 1a/IV, cleared after 3 wk | NA | Nascimbeni et al22 ; Major et al23 | ||
| Ch4×0190 | 1b/IV, cleared after 10 wk | NA | NA | Thomson et al31,32 | ||
| Ch4×0355 | IV, recovered after 9 wk | NA | NA | NA | ||
| Ch6455 | 1a/IV, recovered after 14 wk | NA | NA | Major et al30 | ||
| Ch6461 | 1a/IV, recovered after 18 wk | NA | NA | Major et al30 | ||
| Persistently HCV-infected chimpanzees | ||||||
| Ch6411 | 1a/IV | NA | NA | Major et al30 | ||
| Ch6412 | 1a/IV | NA | NA | Major et al30 | ||
| Ch6475 | 1a/IV | NA | NA | Major et al30 | ||
| Ch1629 | 1a/IV | NA | NA | Major et al30 | ||
| Ch1535 | 1a/IH | NA | NA | Kolykhalov et al33 | ||
| Ch1536 | 1a/IH | NA | NA | Kolykhalov et al33 | ||
Recovery was defined as absence of detectable serum HCV-RNA by real-time RT-PCR.30,32,39
IH indicates intrahepatic inoculation; IV, intravenous inoculation; NA, not applicable.