Overview of BCL6, PAX5, RhoH/TTF, and MYC mutations in PCLBCL, leg type
. | Survival . | . | . | Mutation, position* . | . | . | . | . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | BCL6 . | . | PAX5 . | . | RhoH/TTF . | . | MYC . | . | ||||||||
| Case . | Status . | Time, mo . | AID . | No. . | Mutations . | No. . | Mutations . | No. . | Mutations . | No. . | Mutations . | ||||||||
| 20 | A0 | 75 | Double-positive | 1 | g.835T>C | 2 | g.883C>T, g.1070G>A | 2 | g.574T>G, g.589C>G | 0 | NA | ||||||||
| 21 | D+ | 73 | Double-positive | 1 | g.704G>C | 1 | g.1334C>T | 1 | g.912G>A | 0 | NA | ||||||||
| 22 | D+ | 29 | Double-positive | 2 | g.545G>T, g.661G>A | 0 | NA | 0 | NA | 1 | g.2405delC | ||||||||
| 23 | A0 | 72 | Negative | 0 | NA | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 24 | D+ | 20 | Double-positive | 1 | g.799C>A | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 25 | D+ | 12 | Occasional | 2 | g.552A>C, g.845C>T | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 26 | D0 | 10 | Occasional | 1 | g.837T>G | 0 | NA | 0 | NA | 1 | g.4835G>C, p.Ser146Leu | ||||||||
| 27 | A0 | 31 | Double-positive | 0 | NA | 1 | g.1347G>A | 0 | NA | 0 | NA | ||||||||
| 28 | D+ | 26 | ND | 2 | g.782C>G, g.794G>A | 0 | NA | 2 | g.368G>A, g.682C>T | 0 | NA | ||||||||
| 29 | D+ | 3 | ND | 2 | g.778C>T, g.779G>C | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 30 | D+ | 9 | Negative | 0 | NA | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 31 | A0 | 76 | Double-positive | 0 | NA | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 32 | D+ | 38 | ND | 0 | NA | 0 | NA | 1 | g.306T>C | 0 | NA | ||||||||
. | Survival . | . | . | Mutation, position* . | . | . | . | . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | BCL6 . | . | PAX5 . | . | RhoH/TTF . | . | MYC . | . | ||||||||
| Case . | Status . | Time, mo . | AID . | No. . | Mutations . | No. . | Mutations . | No. . | Mutations . | No. . | Mutations . | ||||||||
| 20 | A0 | 75 | Double-positive | 1 | g.835T>C | 2 | g.883C>T, g.1070G>A | 2 | g.574T>G, g.589C>G | 0 | NA | ||||||||
| 21 | D+ | 73 | Double-positive | 1 | g.704G>C | 1 | g.1334C>T | 1 | g.912G>A | 0 | NA | ||||||||
| 22 | D+ | 29 | Double-positive | 2 | g.545G>T, g.661G>A | 0 | NA | 0 | NA | 1 | g.2405delC | ||||||||
| 23 | A0 | 72 | Negative | 0 | NA | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 24 | D+ | 20 | Double-positive | 1 | g.799C>A | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 25 | D+ | 12 | Occasional | 2 | g.552A>C, g.845C>T | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 26 | D0 | 10 | Occasional | 1 | g.837T>G | 0 | NA | 0 | NA | 1 | g.4835G>C, p.Ser146Leu | ||||||||
| 27 | A0 | 31 | Double-positive | 0 | NA | 1 | g.1347G>A | 0 | NA | 0 | NA | ||||||||
| 28 | D+ | 26 | ND | 2 | g.782C>G, g.794G>A | 0 | NA | 2 | g.368G>A, g.682C>T | 0 | NA | ||||||||
| 29 | D+ | 3 | ND | 2 | g.778C>T, g.779G>C | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 30 | D+ | 9 | Negative | 0 | NA | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 31 | A0 | 76 | Double-positive | 0 | NA | 0 | NA | 0 | NA | 0 | NA | ||||||||
| 32 | D+ | 38 | ND | 0 | NA | 0 | NA | 1 | g.306T>C | 0 | NA | ||||||||
A0 indicates alive without disease; A+, alive with disease; D0, death unrelated to lymphoma; D+, death related to lymphoma; negative, no tumor cells stained; occasional, less than 10% of tumor cells stained; positive, 10% to 50% of tumor cells stained; double-positive, more than 50% of tumor cells stained; and ND, not determined.