Combination therapy with ATRA and SU11657 causes rapid reduction of organ size in leukemic animals
| . | Weight, mg . | |
|---|---|---|
| . | Spleen . | Liver . |
| Placebo | 637 ± 55 | 2593 ± 480 |
| SU11657 | 403 ± 98 | 1950 ± 156 |
| ATRA | 193 ± 56 | 1420 ± 170 |
| SU11657 + ATRA | 90 ± 14 | 1373 ± 95 |
| . | Weight, mg . | |
|---|---|---|
| . | Spleen . | Liver . |
| Placebo | 637 ± 55 | 2593 ± 480 |
| SU11657 | 403 ± 98 | 1950 ± 156 |
| ATRA | 193 ± 56 | 1420 ± 170 |
| SU11657 + ATRA | 90 ± 14 | 1373 ± 95 |
Recipients of leukemic cells were treated for 4 days beginning day 12 after injection. Means ± standard deviations are shown; n = 3 for each group. There was a trend toward smaller spleens and livers in mice treated with SU11657. Organ weights were significantly reduced by ATRA and SU11657 + ATRA treatment (P < .05).