Peripheral blood counts of leukemic FLT3W51/PML-RARα mice
| Mice . | Blood counts . | WBC differential counts, % . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| WBC . | HGB . | Platelets . | Imm/Bl . | Intermediate . | Neutrophils . | Lymphocytes . | Monocytes . | Eosinophils . | |
| Control | 3.9 | 13.5 | 1041 | 0 | 0 | 7.9 | 89.9 | 1.7 | 1 |
| PML-RARα leukemia | 4.5 | 7.8 | 334 | 6.8 | 3.2 | 2 | 87.2 | 0.2 | 0.3 |
| PML-RARα/FLT3W51leukemia | 28.5 | 8.4 | 239 | 32.2 | 10.5 | 4.7 | 51.9 | 0.2 | 0.2 |
| 747 | 25.5 | 8.3 | 194 | 32.5 | 8 | 14 | 45.5 | 0 | 0 |
| 874 | NA | NA | NA | 85 | 1.5 | 2 | 11 | 0.5 | 0.5 |
| 1019 | 15.4 | 7.4 | 102 | 15 | 7 | 5 | 61.5 | 1 | 0 |
| 1020 | 30.3 | 9.6 | 281 | 19 | 7 | 5 | 69 | 0 | 0 |
| 1086 | 6.5 | 6.9 | 289 | 8 | 13 | 2 | 76.5 | 0 | 0.5 |
| 1087 | 13.3 | 7.4 | 318 | 14 | 23 | 6 | 64 | 0 | 0 |
| 1127 | 59.2 | 8.4 | 228 | 39 | 21 | 3.5 | 36 | 0 | 0.5 |
| 1128 | 49.1 | 11.0 | 260 | 45 | 3.5 | 0 | 51.5 | 0 | 0 |
| Mice . | Blood counts . | WBC differential counts, % . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| WBC . | HGB . | Platelets . | Imm/Bl . | Intermediate . | Neutrophils . | Lymphocytes . | Monocytes . | Eosinophils . | |
| Control | 3.9 | 13.5 | 1041 | 0 | 0 | 7.9 | 89.9 | 1.7 | 1 |
| PML-RARα leukemia | 4.5 | 7.8 | 334 | 6.8 | 3.2 | 2 | 87.2 | 0.2 | 0.3 |
| PML-RARα/FLT3W51leukemia | 28.5 | 8.4 | 239 | 32.2 | 10.5 | 4.7 | 51.9 | 0.2 | 0.2 |
| 747 | 25.5 | 8.3 | 194 | 32.5 | 8 | 14 | 45.5 | 0 | 0 |
| 874 | NA | NA | NA | 85 | 1.5 | 2 | 11 | 0.5 | 0.5 |
| 1019 | 15.4 | 7.4 | 102 | 15 | 7 | 5 | 61.5 | 1 | 0 |
| 1020 | 30.3 | 9.6 | 281 | 19 | 7 | 5 | 69 | 0 | 0 |
| 1086 | 6.5 | 6.9 | 289 | 8 | 13 | 2 | 76.5 | 0 | 0.5 |
| 1087 | 13.3 | 7.4 | 318 | 14 | 23 | 6 | 64 | 0 | 0 |
| 1127 | 59.2 | 8.4 | 228 | 39 | 21 | 3.5 | 36 | 0 | 0.5 |
| 1128 | 49.1 | 11.0 | 260 | 45 | 3.5 | 0 | 51.5 | 0 | 0 |
Peripheral blood counts of control, leukemic PML-RARα, and leukemic FLT3W51/PML-RARα mice are shown as mean values along with data from 8 individual FLT3W51/PML-RARα mice. WBC indicates white blood cell count, 1000/μL; HGB, hemoglobin, g/dL; PLT, platelet count, 1000/μL; Imm/Bl, immature forms/blasts; Neutrophils, mature forms, neutrophilic; and NA, not available. Blood counts: control n = 9, PML-RARα leukemias n = 10, FLT3W51/PML-RARα leukemias n = 7. WBC differential counts: control n = 7, PML-RARα leukemias n = 6, FLT3W51/PML-RARα leukemias n = 8. Compared with control, FLT3W51/PML-RARα leukemias show a statistically significant (P < .05) increase in white blood cell count, decrease in hemoglobin levels, decrease in platelet count, increase in immature forms/blasts, and increase in lymphocyte counts. Compared with PML-RARα leukemias, FLT3W51/PML-RARα leukemias show a statistically significant increase in white blood cell counts, increase in immature forms/blasts, increase in intermediate forms, and decrease in lymphocyte counts. Some of the control and PML-RARα leukemia data have been previously reported.28 46