Table 5. Changes in serum total... | American Society of Hematology

Table 5.

Changes in serum total homocysteine,S-adenosylmethionine, cysteine, and glutathione levels after therapy in 3 cobalamin-deficient patients without neurological abnormalities

Patient	Abnormality		Day of Cbl therapy	tHcy level, μM	AdoMet level, nM	Cysteine level, μM	Cys-gly level, μM	GSH level, μM
Patient	CNS	Anemia	Day of Cbl therapy	tHcy level, μM	AdoMet level, nM	Cysteine level, μM	Cys-gly level, μM	GSH level, μM
A	No	Yes	Pretherapy	159.2	54.4	335	67.2	0.5
			14 days	17.0	79.1	181	64.1	2.4
B	No	Yes	Pretherapy	88.9	50.0	316	52.5	1.0
			30 days	11.3	128.3	189	70.9	6.2
C	No	Yes	Pretherapy	122.0	81.8	472	47.7	0.9
			> 90 days	10.9	110.4	174	81.1	6.6

Patient	Abnormality		Day of Cbl therapy	tHcy level, μM	AdoMet level, nM	Cysteine level, μM	Cys-gly level, μM	GSH level, μM
Patient	CNS	Anemia	Day of Cbl therapy	tHcy level, μM	AdoMet level, nM	Cysteine level, μM	Cys-gly level, μM	GSH level, μM
A	No	Yes	Pretherapy	159.2	54.4	335	67.2	0.5
			14 days	17.0	79.1	181	64.1	2.4
B	No	Yes	Pretherapy	88.9	50.0	316	52.5	1.0
			30 days	11.3	128.3	189	70.9	6.2
C	No	Yes	Pretherapy	122.0	81.8	472	47.7	0.9
			> 90 days	10.9	110.4	174	81.1	6.6

Methionine values did not change with therapy and are not shown. See Tables 3 and 4 for abbreviations.

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