Table 1. Effect of rPSGL-Ig treatment on... | American Society of Hematology

Table 1.

Effect of rPSGL-Ig treatment on hemodynamic parameters

Mouse genotype	Treatment	Circulating leukocytes, cells per μL blood		Centerline blood flow velocity, μm/s		Vessel diameter, μm
Mouse genotype	Treatment	Before treatment^*	After treatment^†	Before treatment^*	After treatment^†	Vessel diameter, μm
WT	Surgical stimulation	8200 ± 907	10 167 ± 2161	2157 ± 159	2664 ± 329	51.0 ± 4.1
P-selectin^−/−	TNFα stimulation for 2 hours 30 minutes	4566 ± 753	5 200 ± 1159	2470 ± 413	2891 ± 278	39.8 ± 2.7
E-selectin^−/−	P-selectin blocking antibody + heparin + 6 hours of TNFα	3400 ± 184	3 500 ± 217	2564 ± 357	2782 ± 427	39.4 ± 5.2

Mouse genotype	Treatment	Circulating leukocytes, cells per μL blood		Centerline blood flow velocity, μm/s		Vessel diameter, μm
Mouse genotype	Treatment	Before treatment^*	After treatment^†	Before treatment^*	After treatment^†	Vessel diameter, μm
WT	Surgical stimulation	8200 ± 907	10 167 ± 2161	2157 ± 159	2664 ± 329	51.0 ± 4.1
P-selectin^−/−	TNFα stimulation for 2 hours 30 minutes	4566 ± 753	5 200 ± 1159	2470 ± 413	2891 ± 278	39.8 ± 2.7
E-selectin^−/−	P-selectin blocking antibody + heparin + 6 hours of TNFα	3400 ± 184	3 500 ± 217	2564 ± 357	2782 ± 427	39.4 ± 5.2

Inhibitor treatment was 100 mg/kg throughout.

At 2 minutes before treatment.

At 2 minutes after treatment