Table 8. Reduced capacity of AML cells... | American Society of Hematology

Table 8.

Reduced capacity of AML cells to engraft NOD/SCID mice after exit from G₀

	% G₀^8-150	Cell dose per mouse, ×10⁵	% CD45⁺^8-151
	% G₀^8-150	Cell dose per mouse, ×10⁵	Wk 4	Wk 8	Wk 12
Patient 2
Uncultured	96.6	1	2.6, 0.26	96.5, 83.1	58.2, 53.7
		0.1	0.52, 0.61	5.7, 21.7	6, 12.9
72 h, no GF	38.4	0.2	0.16, 0, 0	0.78, 0, 0	3.73, 0, 0.55
72 h, with GF	5.6	0.2	0, 0, 0.1	0, 0, 0	0, 0, 0
Patient 5
Uncultured	96.2	0.5	5.7, 22.2	77.5, 11.3	89.4, 97.6
		0.1	1.0, 33.6	1.1, 5.3	38.3, 54.3
72 h, no GF	0.8	0.2	0, 0	0, 0	0, 0
72 h, with GF	2.3	0.4	0, 0	0, 0	0.5, 0.42

	% G₀^8-150	Cell dose per mouse, ×10⁵	% CD45⁺^8-151
	% G₀^8-150	Cell dose per mouse, ×10⁵	Wk 4	Wk 8	Wk 12
Patient 2
Uncultured	96.6	1	2.6, 0.26	96.5, 83.1	58.2, 53.7
		0.1	0.52, 0.61	5.7, 21.7	6, 12.9
72 h, no GF	38.4	0.2	0.16, 0, 0	0.78, 0, 0	3.73, 0, 0.55
72 h, with GF	5.6	0.2	0, 0, 0.1	0, 0, 0	0, 0, 0
Patient 5
Uncultured	96.2	0.5	5.7, 22.2	77.5, 11.3	89.4, 97.6
		0.1	1.0, 33.6	1.1, 5.3	38.3, 54.3
72 h, no GF	0.8	0.2	0, 0	0, 0	0, 0
72 h, with GF	2.3	0.4	0, 0	0, 0	0.5, 0.42

GF indicates cultures with the growth factors FL, SF, and IL-3 as described in “Patients, materials, and methods.”

F8-150

Percentage of AML cells injected into mice on day 0 that were in G₀.

F8-151

Percentage of CD45⁺ cells detected in mouse BM at the indicated time after injection of AML cells. Each value is the result for an individual mouse injected with the indicated cell dose on day 0.

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