The sex-restricted relative risk of mild hyperhomocysteinemia conferred by the MTHFR 677TT genotype relative to the 677CC genotype
| tHcy rank . | tHcy concentration, μM . | MTHFR677TT relative to MTHFR 677CC . | ||
|---|---|---|---|---|
| OR . | 95% CI . | P . | ||
| Top 5% | M > 20.8 | 40.8 | 4.7-352.4 | .0008 |
| F > 17.9 | 7.1 | 1.3-38.9 | .02 | |
| Top 10% | M > 14.5 | 11.4 | 3.4-38.7 | .0001 |
| F > 14.3 | 7.1 | 1.7-29.6 | .007 | |
| Top 20% | M > 11.4 | 6.8 | 2.5-19.0 | .0002 |
| F > 11.6 | 2.9 | 1.1-7.6 | .03 | |
| Top 50% | M > 9.2 | 4.2 | 1.5-12.2 | .008 |
| F > 8.6 | 2.4 | 1.0-5.6 | .051 | |
| tHcy rank . | tHcy concentration, μM . | MTHFR677TT relative to MTHFR 677CC . | ||
|---|---|---|---|---|
| OR . | 95% CI . | P . | ||
| Top 5% | M > 20.8 | 40.8 | 4.7-352.4 | .0008 |
| F > 17.9 | 7.1 | 1.3-38.9 | .02 | |
| Top 10% | M > 14.5 | 11.4 | 3.4-38.7 | .0001 |
| F > 14.3 | 7.1 | 1.7-29.6 | .007 | |
| Top 20% | M > 11.4 | 6.8 | 2.5-19.0 | .0002 |
| F > 11.6 | 2.9 | 1.1-7.6 | .03 | |
| Top 50% | M > 9.2 | 4.2 | 1.5-12.2 | .008 |
| F > 8.6 | 2.4 | 1.0-5.6 | .051 | |
tHcy indicates total plasma homocysteine; OR, odds ratio; 95% CI, 95% confidence interval; M, males; and F, females.