Relationships between genotypes and tHcy, folate, red cell folate, and vitamin B12 in young adults
| . | tHcy, μM . | Serum folate, nM . | RCF, μg/L RBCs . | Vitamin B12, pM . |
|---|---|---|---|---|
| MTHFR677C>T | ||||
| CC | 8.8 [4.2-29.5] | 14.0 [5.2-45.0] | 306 [118-1055] | 260 [59-664] |
| CT | 8.7 [4.4-34.0] | 12.1 [3.9-213.0] | 269 [61-770] | 276 [37-1230] |
| TT | 10.3 [5.9-44.6] | 11.0 [3.2-55.6] | 223 [79-958] | 226 [19-537] |
| Anova*, P | < .0005† | .010‡ | < .00052-153 | .0252-155 |
| MTHFR1298A>C | ||||
| AA | 9.2 [4.2-44.6] | 11.6 [3.2-213.0] | 271 [79-1055] | 270 [19-1230] |
| AC | 8.6 [4.4-29.6] | 13.7 [4.9-42.2] | 284 [61-1044] | 266 [108-612] |
| CC | 9.1 [4.7-29.5] | 13.4 [5.6-44.7] | 309 [118-848] | 272 [79-486] |
| Anova*,P | .19 | .51 | .26 | .43 |
| MTR2756A>G | ||||
| AA | 9.2 [4.4-44.6] | 13.3 [3.9-213.0] | 290 [83-1044] | 267 [37-1230] |
| AG | 8.6 [4.2-41.0] | 12.3 [3.2-45.0] | 272 [61-1055] | 276 [19-624] |
| GG | 8.1 [6.3-11.1] | 12.6 [7.2-55.6] | 328 [203-958] | 255 [136-486] |
| Anova*,P | .35 | .72 | .10 | .75 |
| MTRR66A>G | ||||
| AA | 8.5 [4.2-34.0] | 13.4 [3.9-213] | 311 [135-1055] | 270 [19-1230] |
| AG | 9.3 [4.4-41.0] | 12.3 [3.2-55.6] | 268 [61-1044] | 267 [79-664] |
| GG | 9.0 [4.4-44.6] | 14.0 [5.1-34.9] | 302 [135-770] | 275 [59-624] |
| Anova*,P | .07 | .44 | .03 | .59 |
| CBS844ins682-155 | ||||
| WW | 9.0 [4.2-44.6] | 13.0 [3.2-53.2] | 282 [61-1055] | 270 [19-1230] |
| WI | 9.0 [4.6-34.0] | 12.1 [4.9-213.0] | 298 [80-958] | 236 [37-567] |
| II | 7.5 [6.0-12.0] | 15.7 [7.9-44.5] | 233 [154-306] | 267 [164-664] |
| Anova*,P | .50 | .17 | .45 | .33 |
| . | tHcy, μM . | Serum folate, nM . | RCF, μg/L RBCs . | Vitamin B12, pM . |
|---|---|---|---|---|
| MTHFR677C>T | ||||
| CC | 8.8 [4.2-29.5] | 14.0 [5.2-45.0] | 306 [118-1055] | 260 [59-664] |
| CT | 8.7 [4.4-34.0] | 12.1 [3.9-213.0] | 269 [61-770] | 276 [37-1230] |
| TT | 10.3 [5.9-44.6] | 11.0 [3.2-55.6] | 223 [79-958] | 226 [19-537] |
| Anova*, P | < .0005† | .010‡ | < .00052-153 | .0252-155 |
| MTHFR1298A>C | ||||
| AA | 9.2 [4.2-44.6] | 11.6 [3.2-213.0] | 271 [79-1055] | 270 [19-1230] |
| AC | 8.6 [4.4-29.6] | 13.7 [4.9-42.2] | 284 [61-1044] | 266 [108-612] |
| CC | 9.1 [4.7-29.5] | 13.4 [5.6-44.7] | 309 [118-848] | 272 [79-486] |
| Anova*,P | .19 | .51 | .26 | .43 |
| MTR2756A>G | ||||
| AA | 9.2 [4.4-44.6] | 13.3 [3.9-213.0] | 290 [83-1044] | 267 [37-1230] |
| AG | 8.6 [4.2-41.0] | 12.3 [3.2-45.0] | 272 [61-1055] | 276 [19-624] |
| GG | 8.1 [6.3-11.1] | 12.6 [7.2-55.6] | 328 [203-958] | 255 [136-486] |
| Anova*,P | .35 | .72 | .10 | .75 |
| MTRR66A>G | ||||
| AA | 8.5 [4.2-34.0] | 13.4 [3.9-213] | 311 [135-1055] | 270 [19-1230] |
| AG | 9.3 [4.4-41.0] | 12.3 [3.2-55.6] | 268 [61-1044] | 267 [79-664] |
| GG | 9.0 [4.4-44.6] | 14.0 [5.1-34.9] | 302 [135-770] | 275 [59-624] |
| Anova*,P | .07 | .44 | .03 | .59 |
| CBS844ins682-155 | ||||
| WW | 9.0 [4.2-44.6] | 13.0 [3.2-53.2] | 282 [61-1055] | 270 [19-1230] |
| WI | 9.0 [4.6-34.0] | 12.1 [4.9-213.0] | 298 [80-958] | 236 [37-567] |
| II | 7.5 [6.0-12.0] | 15.7 [7.9-44.5] | 233 [154-306] | 267 [164-664] |
| Anova*,P | .50 | .17 | .45 | .33 |
tHcy, serum folate, RCF (red cell folate), and vitamin B12 concentrations are expressed as median [minimum − maximum] values. W indicates wild-type allele; I, insertion allele.
Anova test.
P < .0005 for TT vs CC, and for TT vs CT (t tests, corrected for multiple comparisons).
P < .02 for TT vs CC (t test, corrected for multiple comparisons).
P < .04 for each genotype combination (ttests, corrected for multiple comparisons).
P < .05 for CT vs TT (t test, corrected for multiple comparisons).