Table 2. Effects of in vivo oral... | American Society of Hematology

Table 2.

Effects of in vivo oral treatment with ICA-17043 under ambient and hypoxic conditions

	Wild-type (n = 6)	SAD
	Wild-type (n = 6)	Vehicle (n = 6)	ICA-17043 (n = 6)
Hct, %
Baseline	44.6 ± 1.3	44.4 ± 1.0	44.5 ± 1.1
15 d		43.5 ± 1.8	47.9 ± 1.2^*
Hypoxia	45.2 ± 0.9	44.9 ± 1.7	45.0 ± 1.1
Erythrocyte density (D₅₀)
Baseline	1.092 ± 0.003	1.101 ± 0.003	1.100 ± 0.001
15 d		1.102 ± 0.001	1.093 ± 0.001^*
Hypoxia	1.093 ± 0.001	1.112 ± 0.001^*	1.103 ± 0.001^†
Gardos channel Rb⁺ flux, mmol/L cell × min
Baseline	12.1 ± 0.3	11.7 ± 0.9	11.8 ± 1.3
15 d		12.4 ± 1.5	3.7 ± 2.8^*,^†
Hypoxia	11.6 ± 1.1	10.9 ± 2.1	3.5 ± 0.6^*,^†
Erythrocyte K content, mmol/kg Hb
Baseline	489.7 ± 10.6	307.7 ± 7.6	330.5 ± 18.1
15 d		321.7 ± 11.9	452.3 ± 24.8^*
Hypoxia	490.5 ± 14.2	279.3 ± 24.7^*	321.6 ± 22.0^†

	Wild-type (n = 6)	SAD
	Wild-type (n = 6)	Vehicle (n = 6)	ICA-17043 (n = 6)
Hct, %
Baseline	44.6 ± 1.3	44.4 ± 1.0	44.5 ± 1.1
15 d		43.5 ± 1.8	47.9 ± 1.2^*
Hypoxia	45.2 ± 0.9	44.9 ± 1.7	45.0 ± 1.1
Erythrocyte density (D₅₀)
Baseline	1.092 ± 0.003	1.101 ± 0.003	1.100 ± 0.001
15 d		1.102 ± 0.001	1.093 ± 0.001^*
Hypoxia	1.093 ± 0.001	1.112 ± 0.001^*	1.103 ± 0.001^†
Gardos channel Rb⁺ flux, mmol/L cell × min
Baseline	12.1 ± 0.3	11.7 ± 0.9	11.8 ± 1.3
15 d		12.4 ± 1.5	3.7 ± 2.8^*,^†
Hypoxia	11.6 ± 1.1	10.9 ± 2.1	3.5 ± 0.6^*,^†
Erythrocyte K content, mmol/kg Hb
Baseline	489.7 ± 10.6	307.7 ± 7.6	330.5 ± 18.1
15 d		321.7 ± 11.9	452.3 ± 24.8^*
Hypoxia	490.5 ± 14.2	279.3 ± 24.7^*	321.6 ± 22.0^†

Data are presented as means ± SD.

P < .05 compared with baseline.

P < .005 treated versus untreated SAD mice.