Genome-wide analysis of DNA copy-number changes using array CGH in FCL and transformed/relapsed biopsies
| Case no. . | Genomic changes at diagnosis . | Genomic changes at transformed and relapse . |
|---|---|---|
| IL105 | −1p36, +1q21qter,* −6q22qter,* −8p23.1, +8p22,* −9p21 (P16locus), +16p11pter, −17p11pter, +18 | −5q21q23,†+17q11qter† |
| IL114 | Normal | +1q24,†,‡ +2p16 (RELlocus),†,‡ −4,† +5p12p15,† −6q11qter,† +7,† +9p23p24,†+9q13q31,† −9q31qter,† +10,† −11q11qter,† +12pter-q14,† +12q12,†,‡ −13q11qter,† −15q23,† +16, −17p12pter,† +18q11qter,†+20,† +Xq21qter† |
| IL116 | −1p33p36, +1q24qter, +2p16 (REL locus), −4q34qter, −6q11qter, +8q24, +13q21q31, −13q33qter, +17q21q22, +18pter-q21.3,* −18q21.3qter* | +2p16 (REL locus), †,‡ +6p11pter† |
| IL117 | −13q14, +18pter-q21.3 | Same alterations |
| IL119 | Normal | Normal |
| IL120 | −11p14, +15q14, +17p12, +17q21, +18pter-q21.3 | −1p36,† −13q14 (RB locus),†+17q11qter† |
| IL121 | −9p21 (P16 locus), −X* | +18pter-q21.3,† +X† |
| IL123 | −1p36,* +1q21qter,* +2,*+18pter-q21.3 | +21q11qter† |
| IL124 | −6q11qter, −9p11pter, −13q21, −13q31, +17 | +4p11pter,† −4q21qter,† +12 |
| IL126 | −1p34p36,* +1q21qter,* +1q32.1,*,‡ −4, +6p21,*−6q22q24,* +13q32,* −14q12q22,* +15q11q14, −17p11pter,*+17q11-qter,* +18q21.3* | +3q12qter,† −13q21.1† |
| IL111 | −3q28, +8, +18pter-q21.3 | +2p11p25,†,2-153 +3q27q29†,2-153 |
| IL112 | −1p35p36, +8p23.2 | +4p11pter,†,2-153 −8p12p23,†,2-153−9p21.3,†,2-153 +17q21.3†,2-153 |
| Case no. . | Genomic changes at diagnosis . | Genomic changes at transformed and relapse . |
|---|---|---|
| IL105 | −1p36, +1q21qter,* −6q22qter,* −8p23.1, +8p22,* −9p21 (P16locus), +16p11pter, −17p11pter, +18 | −5q21q23,†+17q11qter† |
| IL114 | Normal | +1q24,†,‡ +2p16 (RELlocus),†,‡ −4,† +5p12p15,† −6q11qter,† +7,† +9p23p24,†+9q13q31,† −9q31qter,† +10,† −11q11qter,† +12pter-q14,† +12q12,†,‡ −13q11qter,† −15q23,† +16, −17p12pter,† +18q11qter,†+20,† +Xq21qter† |
| IL116 | −1p33p36, +1q24qter, +2p16 (REL locus), −4q34qter, −6q11qter, +8q24, +13q21q31, −13q33qter, +17q21q22, +18pter-q21.3,* −18q21.3qter* | +2p16 (REL locus), †,‡ +6p11pter† |
| IL117 | −13q14, +18pter-q21.3 | Same alterations |
| IL119 | Normal | Normal |
| IL120 | −11p14, +15q14, +17p12, +17q21, +18pter-q21.3 | −1p36,† −13q14 (RB locus),†+17q11qter† |
| IL121 | −9p21 (P16 locus), −X* | +18pter-q21.3,† +X† |
| IL123 | −1p36,* +1q21qter,* +2,*+18pter-q21.3 | +21q11qter† |
| IL124 | −6q11qter, −9p11pter, −13q21, −13q31, +17 | +4p11pter,† −4q21qter,† +12 |
| IL126 | −1p34p36,* +1q21qter,* +1q32.1,*,‡ −4, +6p21,*−6q22q24,* +13q32,* −14q12q22,* +15q11q14, −17p11pter,*+17q11-qter,* +18q21.3* | +3q12qter,† −13q21.1† |
| IL111 | −3q28, +8, +18pter-q21.3 | +2p11p25,†,2-153 +3q27q29†,2-153 |
| IL112 | −1p35p36, +8p23.2 | +4p11pter,†,2-153 −8p12p23,†,2-153−9p21.3,†,2-153 +17q21.3†,2-153 |
Listed samples nos. IL105 to IL126 were classified as transformed DLBCL. Biopsies nos. IL111 and IL112 were classified as nontransformed relapse.
Genomic abnormalities in the column of genomic changes at diagnosis indicate changes observed in the diagnostic sample that were not seen in the transformation specimen.
Genomic abnormalities in the transformed/relapsed samples column identified in only one of the sequential biopsies, thus representing losses or gains upon transformation or relapse. Only the acquired changes that were not present in the initial biopsies are shown
Genomic abnormalities that represent high-level amplifications.
Abnormalities acquired in nontransformed biopsies (IL111 and IL112).