AcSDKP enhances the secretion of active form of MMP-1
| . | MMP-1 . | MMP-2 . | ||
|---|---|---|---|---|
| . | A . | T . | A . | T . |
| Control | 36 ± 9 | 145 ± 23 | 22 ± 10 | 110 ± 31 |
| AcSDKP, 10−9M | 67 ± 9* | 164 ± 14 | 28 ± 6 | 120 ± 6 |
| AcSDKP, 10−11M | 50 ± 7† | 143 ± 9 | 21 ± 1 | 122 ± 7 |
| . | MMP-1 . | MMP-2 . | ||
|---|---|---|---|---|
| . | A . | T . | A . | T . |
| Control | 36 ± 9 | 145 ± 23 | 22 ± 10 | 110 ± 31 |
| AcSDKP, 10−9M | 67 ± 9* | 164 ± 14 | 28 ± 6 | 120 ± 6 |
| AcSDKP, 10−11M | 50 ± 7† | 143 ± 9 | 21 ± 1 | 122 ± 7 |
EA.hy926 cells were grown for 24 hours in serum-free DMEM in the presence or absence (control) of AcSDKP. Active (A) or total (T: pro + active) secreted forms of MMP-1 and MMP-2 were quantified by specific ELISA in EA.hy926 cell–conditioned media and calculated in ng/106 cells. Results are expressed as the mean ± SEM of 6 independent experiments.
P < .01.
P < .05.