Table 1. Effect of W v and Nf1 genotypes... | American Society of Hematology

Table 1.

Effect of W^v and Nf1genotypes on spleen weight, splenic cellularity, WBC count, and total number of HPP-CFCs and LPP-CFCs per spleen in primary recipients

	Genotype
	Nf1^+/+;W^v+/+	W^v/W^v;Nf1^+/+	W^v+/+;Nf1^−/−	W^v/W^v;Nf1^−/−
Spleen weight, mg	73.0	66.0	294.0	298.0
Splenic cellularity, total cells × 10⁸	1.41	1.06	4.24	4.91
WBC count, ×10⁶	18.3	17.2	17.5	6.6
Total HPP-CFC/spleen	1300 ± 650	1663 ± 286	17 453 ± 2717^*	24 240 ± 1 171^*
Total LPP-CFC/spleen	6500 ± 1300	6995 ± 1116	192 610 ± 15 571^*	196 220 ± 11 953^*

	Genotype
	Nf1^+/+;W^v+/+	W^v/W^v;Nf1^+/+	W^v+/+;Nf1^−/−	W^v/W^v;Nf1^−/−
Spleen weight, mg	73.0	66.0	294.0	298.0
Splenic cellularity, total cells × 10⁸	1.41	1.06	4.24	4.91
WBC count, ×10⁶	18.3	17.2	17.5	6.6
Total HPP-CFC/spleen	1300 ± 650	1663 ± 286	17 453 ± 2717^*	24 240 ± 1 171^*
Total LPP-CFC/spleen	6500 ± 1300	6995 ± 1116	192 610 ± 15 571^*	196 220 ± 11 953^*

Spleen weight, splenic cellularity, white blood cell counts, and total numbers of HPP-CFCs and LPP-CFCs per spleen were measured in primary recipients of transplanted fetal liver cells from the 4 F2 experimental groups (outlined in “Study design”) 4 months after transplantation. Total numbers of HPP-CFCs and LPP-CFCs per spleen represent the mean number of colonies ± SEM in 3 replicate experiments from spleen cells harvested from the same primary recipient.

P < .05 for comparisons ofNf1^−/−;W^v/W^v orNf1^−/−;W^v+/+ versusNf1^+/+;W^v+/+ primary recipients by paired Student t test.

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