Table 1. HC-Ad safety evaluation in... | American Society of Hematology

Table 1.

HC-Ad safety evaluation in hemophilia A dog model

	Serum chemistry values								Hematology
	ALT, U/L	AST, U/L	ALK P, U/L	Bili, μM	Urea, mM	Creat, μM	CK, U/L	Alb, g/L	Iron, μM	Platelet, × 10⁹/L	RBC, × 10¹²/L	WBC, × 10⁹/L	Hg, g/L	MCV, fL	FGN, g/L	FDP, ng/mL
Baseline	54	28	56	3	4.9	49	244	—	—	304	7.7	10	180	67.6	—	Normal
Preinjection	50	22	44	3	2.8	50	122	34	21	233	7.1	7.3	164	68.1	1.7	Normal
5 h	53	26	51	3	5.0	44	145	36	17	253	7.2	14.5	170	68.1	1.9	Normal
1 d	51	24	61	3	2.5	48	148	34	24	220	6.5	4.9	151	68.7	2.6	Normal
2 d	56	24	56	2	2.8	47	102	34	32	219	7.4	6.9	174	69.0	2.2	Normal
3 d	51	25	49	3	3.2	46	106	33	26	221	6.9	7.9	160	67.8	1.7	Normal
7 d	45	20	44	2	4.3	50	94	34	28	220	6.7	8.4	155	69.2	1.9	Normal
10 d	48	22	46	2	4.1	52	105	35	31	251	7.0	8.8	165	69.2	1.9	Normal
14 d	56	27	53	—	2.7	42	104	35	33	257	7.7	7.4	178	68.8	2.2	Normal
21 d	—	—	—	—	—	—	—	—	—	—	—	—	—	—	1.8	Normal
28 d	64	24	48	—	3.3	43	125	36	25	264	7.8	6.7	180	69.0	1.4	Normal
35 d	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—

	Serum chemistry values								Hematology
	ALT, U/L	AST, U/L	ALK P, U/L	Bili, μM	Urea, mM	Creat, μM	CK, U/L	Alb, g/L	Iron, μM	Platelet, × 10⁹/L	RBC, × 10¹²/L	WBC, × 10⁹/L	Hg, g/L	MCV, fL	FGN, g/L	FDP, ng/mL
Baseline	54	28	56	3	4.9	49	244	—	—	304	7.7	10	180	67.6	—	Normal
Preinjection	50	22	44	3	2.8	50	122	34	21	233	7.1	7.3	164	68.1	1.7	Normal
5 h	53	26	51	3	5.0	44	145	36	17	253	7.2	14.5	170	68.1	1.9	Normal
1 d	51	24	61	3	2.5	48	148	34	24	220	6.5	4.9	151	68.7	2.6	Normal
2 d	56	24	56	2	2.8	47	102	34	32	219	7.4	6.9	174	69.0	2.2	Normal
3 d	51	25	49	3	3.2	46	106	33	26	221	6.9	7.9	160	67.8	1.7	Normal
7 d	45	20	44	2	4.3	50	94	34	28	220	6.7	8.4	155	69.2	1.9	Normal
10 d	48	22	46	2	4.1	52	105	35	31	251	7.0	8.8	165	69.2	1.9	Normal
14 d	56	27	53	—	2.7	42	104	35	33	257	7.7	7.4	178	68.8	2.2	Normal
21 d	—	—	—	—	—	—	—	—	—	—	—	—	—	—	1.8	Normal
28 d	64	24	48	—	3.3	43	125	36	25	264	7.8	6.7	180	69.0	1.4	Normal
35 d	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—

— indicates not determined.