Summary of FA cohort reports
| Cohort . | LIT . | IFAR . | NAS . | P* . |
|---|---|---|---|---|
| Reporting period or date | 1927-2001 | 1982-2001 | 2000 | — |
| Total number of subjects | 1301 | 754 | 145 | — |
| Male-to-female ratio | 1.23 | 1.05 | 1.10 | ns |
| Age FA diagnosed, median (range) | 7 (0-48) | na | 5 (0-45) | <.0002 |
| Deceased %, at time of report | 38% | 38% | 30% | ns |
| Projected median survival age, years | 20 | 24 | 30 | — |
| Leukemia, no MDS; number (% total cohort) | 116 (9%) | 47 (6%) | 9 (6%) | <.05 |
| Leukemia, cumulative incidence | na | 45% by age 50 (includes MDS) | 10% by age 24 (no MDS) | — |
| MDS, number (% total cohort) | 89 (7%) | 53 (7%) | 23 (16%) | .001 |
| Solid tumor, number (% total cohort) | 68 (5%) | 67 (9%) | 13 (9%) | .003 |
| Solid tumor, cumulative incidence | na | 36% by age 50 | 29% by age 48 | — |
| Liver tumor, number (% total cohort) | 37 (3%) | 18 (2%) | 2 (1%) | ns |
| Hematopoietic stem cell transplant (% total cohort) | 220 (17%) | 219 (29%) | 44 (30%) | <.0001 |
| Cohort . | LIT . | IFAR . | NAS . | P* . |
|---|---|---|---|---|
| Reporting period or date | 1927-2001 | 1982-2001 | 2000 | — |
| Total number of subjects | 1301 | 754 | 145 | — |
| Male-to-female ratio | 1.23 | 1.05 | 1.10 | ns |
| Age FA diagnosed, median (range) | 7 (0-48) | na | 5 (0-45) | <.0002 |
| Deceased %, at time of report | 38% | 38% | 30% | ns |
| Projected median survival age, years | 20 | 24 | 30 | — |
| Leukemia, no MDS; number (% total cohort) | 116 (9%) | 47 (6%) | 9 (6%) | <.05 |
| Leukemia, cumulative incidence | na | 45% by age 50 (includes MDS) | 10% by age 24 (no MDS) | — |
| MDS, number (% total cohort) | 89 (7%) | 53 (7%) | 23 (16%) | .001 |
| Solid tumor, number (% total cohort) | 68 (5%) | 67 (9%) | 13 (9%) | .003 |
| Solid tumor, cumulative incidence | na | 36% by age 50 | 29% by age 48 | — |
| Liver tumor, number (% total cohort) | 37 (3%) | 18 (2%) | 2 (1%) | ns |
| Hematopoietic stem cell transplant (% total cohort) | 220 (17%) | 219 (29%) | 44 (30%) | <.0001 |
ns indicates not statistically significant; na, not available; and —, data in rows could not be subjected to test for significance.
P value indicates significance of data at the extremes.