Table 1.

Relationship between WT1 level after transplantation and risk of relapse

LevelWT1 levelNo.HR (%)Imminent relapseCR‡
within 40 d (%)		Median lead time (d)Ultimate relapse rate, %
20 d* (%)40 d† (%)
A 5.0 × 10−2 ≤WT1 12 12 (100) 0 (0) 0 (0) 0 (0)   01-153 100 
B 1.0 × 10−2 ≤ WT1 < 5.0 × 10−2 13 6 (46.2) 7 (53.4) 0 (0) 0 (0)  111-153 1001-154 
C 4.0 × 10−3 ≤ WT1 < 1.0 × 10−2 9 0 (0) 2 (22.2) 2 (22.2) 5 (55.6)  431-153 77.81-154 
D 4.0 × 10−4 ≤ WT1 < 4.0 × 10−3 78 0 (0) 3 (3.8) 5 (6.4) 70 (89.7)  921-153 29.71-154 
E WT1 < 4.0 × 10−4 255 0 (0) 0 (0) 2 (0.8) 253 (99.2) 1441-155 17.1# 
LevelWT1 levelNo.HR (%)Imminent relapseCR‡
within 40 d (%)		Median lead time (d)Ultimate relapse rate, %
20 d* (%)40 d† (%)
A 5.0 × 10−2 ≤WT1 12 12 (100) 0 (0) 0 (0) 0 (0)   01-153 100 
B 1.0 × 10−2 ≤ WT1 < 5.0 × 10−2 13 6 (46.2) 7 (53.4) 0 (0) 0 (0)  111-153 1001-154 
C 4.0 × 10−3 ≤ WT1 < 1.0 × 10−2 9 0 (0) 2 (22.2) 2 (22.2) 5 (55.6)  431-153 77.81-154 
D 4.0 × 10−4 ≤ WT1 < 4.0 × 10−3 78 0 (0) 3 (3.8) 5 (6.4) 70 (89.7)  921-153 29.71-154 
E WT1 < 4.0 × 10−4 255 0 (0) 0 (0) 2 (0.8) 253 (99.2) 1441-155 17.1# 
*

Patients were in CR at the time of the WT1test but relapsed within 20 days.

†

Patients were in CR at the time of the WT1 test but relapsed in between 20 and 40 days.

‡

Patients were in CR at the time of the WT1 test and remained in CR for at least 40 days.

F1-153

In relapsed patients, the median length of time from the first increase of WT1 expression to each MRD level until a diagnosis of HR.

F1-155

In relapsed patients, the median length of time from the MRD− state (level E) until a diagnosis of HR.

F1-154

The ultimate relapse rate of patients in whom WT1 levels showed each MRD level even once after transplantation.

#The ultimate relapse rate of patients in whom WT1 levels showed level E twice in succession after transplantation.

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