Phenotypic reconstitution of mononuclear cell subsets 3 months and 12 months after transplantation
| . | BMT cells/μL . | PBSC cells/μL . | CD34+-PBSC cells/μL . | P CD34-PBSCT vs BMT/ CD34-PBSCT vs PBSCT . |
|---|---|---|---|---|
| 3 months after transplantation | n = 12 | n = 16 | n = 22 | |
| CD3+CD4+T cells T helper cells | 116.5 ± 90 | 250.5 ± 146 | 51 ± 92 | NS/< .001 |
| CD3+CD4+CD45RA+ naive T helper cells | 11.0 ± 11 | 54 ± 45 | 1 ± 10 | < .001/< .001 |
| CD3+CD4+CD45R0+ memory T helper cells | 87.0 ± 89 | 127.5 ± 139 | 54 ± 90 | NS/< .03 |
| CD3+CD8+ T cells | 150 ± 377 | 455 ± 718 | 153 ± 385 | NS/NS |
| CD4/CD8 ratio | 0.6 ± 0.7 | 0.65 ± 0.6 | 0.45 ± 1.4 | NS/NS |
| CD19+ B cells | 10.0 ± 41 | 27.5 ± 99 | 277 ± 173 | < .001/< .001 |
| Monocytes | 440 ± 481 | 477 ± 270 | 434 ± 288 | NS/NS |
| NK cells | 166 ± 92 | 147 ± 147 | 288 ± 257 | < .02/.01 |
| 12 months after transplantation | n = 11 | n = 15 | n = 20 | |
| CD3+CD4+T cells T helper cells | 265 ± 187 | 366 ± 146 | 233 ± 131 | NS/< .06 |
| CD3+CD4+CD45RA+ naive T helper cells | 46 ± 66 | 71 ± 61 | 22 ± 50 | NS/NS |
| CD3+CD4+CD45R0+ memory T helper cells | 173 ± 149 | 264 ± 104 | 158 ± 110 | NS/NS |
| CD3+CD8+ T cells | 272 ± 752 | 667 ± 555 | 488 ± 404 | NS/NS |
| CD4/CD8 ratio | 1.0 ± 0.7 | 0.6 ± 0.6 | 0.5 ± 0.7 | NS/NS |
| CD19+ B cells | 232 ± 242 | 117 ± 135 | 383 ± 348 | < .01/< .01 |
| Monocytes | 486 ± 247 | 432 ± 206 | 330 ± 211 | NS/NS |
| NK cells | 212 ± 190 | 117 ± 60 | 173 ± 180 | NS/NS |
| . | BMT cells/μL . | PBSC cells/μL . | CD34+-PBSC cells/μL . | P CD34-PBSCT vs BMT/ CD34-PBSCT vs PBSCT . |
|---|---|---|---|---|
| 3 months after transplantation | n = 12 | n = 16 | n = 22 | |
| CD3+CD4+T cells T helper cells | 116.5 ± 90 | 250.5 ± 146 | 51 ± 92 | NS/< .001 |
| CD3+CD4+CD45RA+ naive T helper cells | 11.0 ± 11 | 54 ± 45 | 1 ± 10 | < .001/< .001 |
| CD3+CD4+CD45R0+ memory T helper cells | 87.0 ± 89 | 127.5 ± 139 | 54 ± 90 | NS/< .03 |
| CD3+CD8+ T cells | 150 ± 377 | 455 ± 718 | 153 ± 385 | NS/NS |
| CD4/CD8 ratio | 0.6 ± 0.7 | 0.65 ± 0.6 | 0.45 ± 1.4 | NS/NS |
| CD19+ B cells | 10.0 ± 41 | 27.5 ± 99 | 277 ± 173 | < .001/< .001 |
| Monocytes | 440 ± 481 | 477 ± 270 | 434 ± 288 | NS/NS |
| NK cells | 166 ± 92 | 147 ± 147 | 288 ± 257 | < .02/.01 |
| 12 months after transplantation | n = 11 | n = 15 | n = 20 | |
| CD3+CD4+T cells T helper cells | 265 ± 187 | 366 ± 146 | 233 ± 131 | NS/< .06 |
| CD3+CD4+CD45RA+ naive T helper cells | 46 ± 66 | 71 ± 61 | 22 ± 50 | NS/NS |
| CD3+CD4+CD45R0+ memory T helper cells | 173 ± 149 | 264 ± 104 | 158 ± 110 | NS/NS |
| CD3+CD8+ T cells | 272 ± 752 | 667 ± 555 | 488 ± 404 | NS/NS |
| CD4/CD8 ratio | 1.0 ± 0.7 | 0.6 ± 0.6 | 0.5 ± 0.7 | NS/NS |
| CD19+ B cells | 232 ± 242 | 117 ± 135 | 383 ± 348 | < .01/< .01 |
| Monocytes | 486 ± 247 | 432 ± 206 | 330 ± 211 | NS/NS |
| NK cells | 212 ± 190 | 117 ± 60 | 173 ± 180 | NS/NS |
PBC indicates peripheral blood cell. PBC counts (mean ± SEM) are given for helper T cells, naive T cells, and memory T cells, as well as CD8+ T cells, CD19+ B cells, NK cells, monocytes, and CD4/CD8 ratios for patients after bone marrow transplant (BMT), peripheral blood stem cell transplantation (PBSCT), or transplantation of highly purified CD34+ cells (CD34+-PBSCT). Significances were tested by comparing CD34+-PBSCT versus BMT and CD34+-PBSCT versus PBSCT.