VH gene usage and relationship with mutation frequency and clinical data at diagnosis
| VH gene . | Frequency in CD5+IgM+ PBLs22 23, % . | MCL cases . | Mutation more than 2% . | Mean no. of mutations . | Splenomegaly at diagnosis . | PB/BM infiltration . | I/II CS . | Waldeyer . | Intestinal . | Survival longer than 5 y . |
|---|---|---|---|---|---|---|---|---|---|---|
| VH1-08 | — | 7 | 1 | 0.70 | 0 | 2 | 2 | 1 | 1 | 1 |
| VH1-18 | 3.5 | 3 | 0 | 0.60 | 0 | 2 | 1 | 2 | 0 | 0 |
| VH3-07 | 5.6 | 6 | 3 | 2.00 | 1 | 3 | 0 | 0 | 0 | 1 |
| VH3-09 | — | 6 | 1 | 0.67 | 4 | 3 | 1 | 0 | 0 | 1 |
| VH3-21 | — | 10 | 0 | 0.18 | 1 | 3 | 1 | 0 | 0 | 4 |
| VH3-23 | 13.9 | 9 | 5 | 3.28 | 5 | 6 | 0 | 0 | 2 | 0 |
| VH3-48 | — | 3 | 3 | 5.82 | 1 | 1 | 0 | 0 | 0 | 1 |
| VH4-34 | 3.5 | 11 | 3 | 1.22 | 3 | 6 | 1 | 2 | 0 | 3 |
| VH4-39 | 2.8 | 7 | 3 | 2.84 | 1 | 4 | 0 | 0 | 0 | 1 |
| VH4-59 | 6.3 | 9 | 1 | 1.53 | 4 | 7 | 0 | 0 | 1 | 4 |
| Others | — | 25 | 8 | 3.03 | 6 | 14 | 2 | 2 | 3 | 2 |
| Total | NA | 96 | 28 | 1.94 | 26 | 51 | 8 | 7 | 7 | 18 |
| Significance | NA | NA | P < .001 | NS | NS | NS | NS | NS | NS | |
| VH gene . | Frequency in CD5+IgM+ PBLs22 23, % . | MCL cases . | Mutation more than 2% . | Mean no. of mutations . | Splenomegaly at diagnosis . | PB/BM infiltration . | I/II CS . | Waldeyer . | Intestinal . | Survival longer than 5 y . |
|---|---|---|---|---|---|---|---|---|---|---|
| VH1-08 | — | 7 | 1 | 0.70 | 0 | 2 | 2 | 1 | 1 | 1 |
| VH1-18 | 3.5 | 3 | 0 | 0.60 | 0 | 2 | 1 | 2 | 0 | 0 |
| VH3-07 | 5.6 | 6 | 3 | 2.00 | 1 | 3 | 0 | 0 | 0 | 1 |
| VH3-09 | — | 6 | 1 | 0.67 | 4 | 3 | 1 | 0 | 0 | 1 |
| VH3-21 | — | 10 | 0 | 0.18 | 1 | 3 | 1 | 0 | 0 | 4 |
| VH3-23 | 13.9 | 9 | 5 | 3.28 | 5 | 6 | 0 | 0 | 2 | 0 |
| VH3-48 | — | 3 | 3 | 5.82 | 1 | 1 | 0 | 0 | 0 | 1 |
| VH4-34 | 3.5 | 11 | 3 | 1.22 | 3 | 6 | 1 | 2 | 0 | 3 |
| VH4-39 | 2.8 | 7 | 3 | 2.84 | 1 | 4 | 0 | 0 | 0 | 1 |
| VH4-59 | 6.3 | 9 | 1 | 1.53 | 4 | 7 | 0 | 0 | 1 | 4 |
| Others | — | 25 | 8 | 3.03 | 6 | 14 | 2 | 2 | 3 | 2 |
| Total | NA | 96 | 28 | 1.94 | 26 | 51 | 8 | 7 | 7 | 18 |
| Significance | NA | NA | P < .001 | NS | NS | NS | NS | NS | NS | |
Most frequent IgVH genes in relation to mutational index and several clinically relevant features. Only productive rearrangements have been considered in those 7 cases with double rearrangements. CS indicates clinical stage; NA, not available; NS, not significant; —, data not shown.