Systemic hemodynamic parameters during the mesenteric I/R protocol in FPR KO mice
| Experimental group . | Preocclusion, −5 minutes . | Occlusion, 0 minutes . | Reperfusion . | |
|---|---|---|---|---|
| R = 0 minutes . | R = 45 minutes . | |||
| Sham | ||||
| MABP | 51 ± 1 | 53 ± 4 | 48 ± 3 | 41 ± 2 |
| HR | 337 ± 96 | 441 ± 90 | 413 ± 99 | 318 ± 85 |
| PRI | 17 ± 5 | 24 ± 6 | 19 ± 4 | 14 ± 4 |
| PBS | ||||
| MABP | 52 ± 7 | 59 ± 3 | 45 ± 6 | 35 ± 6 |
| HR | 424 ± 73 | 369 ± 127 | 417 ± 66 | 455 ± 57 |
| PRI | 21 ± 1 | 20 ± 6 | 17 ± 2 | 16 ± 2 |
| Peptide Ac2-26 | ||||
| MABP | 53 ± 10 | 56 ± 8 | 41 ± 4 | 36 ± 1 |
| HR | 181 ± 43* | 198 ± 32 | 209 ± 25 | 359 ± 119 |
| PRI | 9 ± 3 | 31 ± 18 | 9 ± 2 | 13 ± 4 |
| Experimental group . | Preocclusion, −5 minutes . | Occlusion, 0 minutes . | Reperfusion . | |
|---|---|---|---|---|
| R = 0 minutes . | R = 45 minutes . | |||
| Sham | ||||
| MABP | 51 ± 1 | 53 ± 4 | 48 ± 3 | 41 ± 2 |
| HR | 337 ± 96 | 441 ± 90 | 413 ± 99 | 318 ± 85 |
| PRI | 17 ± 5 | 24 ± 6 | 19 ± 4 | 14 ± 4 |
| PBS | ||||
| MABP | 52 ± 7 | 59 ± 3 | 45 ± 6 | 35 ± 6 |
| HR | 424 ± 73 | 369 ± 127 | 417 ± 66 | 455 ± 57 |
| PRI | 21 ± 1 | 20 ± 6 | 17 ± 2 | 16 ± 2 |
| Peptide Ac2-26 | ||||
| MABP | 53 ± 10 | 56 ± 8 | 41 ± 4 | 36 ± 1 |
| HR | 181 ± 43* | 198 ± 32 | 209 ± 25 | 359 ± 119 |
| PRI | 9 ± 3 | 31 ± 18 | 9 ± 2 | 13 ± 4 |
Changes in mean arterial blood pressure (MABP, mm Hg), heart rate (HR, beats/min), and pressure-rate index (PRI, mm Hg/min/103) recorded in anesthetized mice before (preocclusion), during 30 minutes of superior mesenteric artery occlusion, and up to 45 minutes of reperfusion. Mice received either PBS (0.1 mL) or peptide Ac2-26 (100 μg equivalent to 33 nmol) before reperfusion (R = 0). A sham group was also included. Data are mean ± SEM of n = 4 mice per group.