Systemic hemodynamic parameters during the mesenteric I/R protocol in WT mice
| Experimental group . | Preocclusion, −5 minutes . | Occlusion, 0 minutes . | Reperfusion . | |
|---|---|---|---|---|
| R = 0 minutes . | R = 45 minutes . | |||
| Sham | ||||
| MABP | 51 ± 7 | 59 ± 5 | 45 ± 4 | 53 ± 6* |
| HR | 315 ± 65 | 260 ± 89 | 341 ± 87 | 404 ± 65 |
| PRI | 16 ± 3 | 16 ± 5 | 26 ± 9 | 22 ± 3 |
| PBS | ||||
| MABP | 50 ± 6 | 48 ± 10 | 34 ± 3 | 32 ± 3 |
| HR | 412 ± 55 | 321 ± 22 | 349 ± 17 | 421 ± 90 |
| PRI | 20 ± 2 | 13 ± 1 | 12 ± 2 | 14 ± 4 |
| Peptide Ac2-26 | ||||
| MABP | 61 ± 11 | 62 ± 10 | 57 ± 8 | 41 ± 4 |
| HR | 327 ± 30 | 240 ± 62 | 273 ± 49 | 315 ± 46 |
| PRI | 20 ± 5 | 15 ± 3 | 16 ± 3 | 13 ± 3 |
| Experimental group . | Preocclusion, −5 minutes . | Occlusion, 0 minutes . | Reperfusion . | |
|---|---|---|---|---|
| R = 0 minutes . | R = 45 minutes . | |||
| Sham | ||||
| MABP | 51 ± 7 | 59 ± 5 | 45 ± 4 | 53 ± 6* |
| HR | 315 ± 65 | 260 ± 89 | 341 ± 87 | 404 ± 65 |
| PRI | 16 ± 3 | 16 ± 5 | 26 ± 9 | 22 ± 3 |
| PBS | ||||
| MABP | 50 ± 6 | 48 ± 10 | 34 ± 3 | 32 ± 3 |
| HR | 412 ± 55 | 321 ± 22 | 349 ± 17 | 421 ± 90 |
| PRI | 20 ± 2 | 13 ± 1 | 12 ± 2 | 14 ± 4 |
| Peptide Ac2-26 | ||||
| MABP | 61 ± 11 | 62 ± 10 | 57 ± 8 | 41 ± 4 |
| HR | 327 ± 30 | 240 ± 62 | 273 ± 49 | 315 ± 46 |
| PRI | 20 ± 5 | 15 ± 3 | 16 ± 3 | 13 ± 3 |
Changes in mean arterial blood pressure (MABP, mm Hg), heart rate (HR, beats/min), and pressure-rate index (PRI, mm Hg/min/103) recorded in anesthetized mice before (preocclusion), during 30 minutes of superior mesenteric artery occlusion, and up to 45 minutes of reperfusion. Mice received either PBS (0.1 mL) or peptide Ac2-26 (100 μg equivalent to 33 nmol) before reperfusion (R = 0). A sham group was also included. Data are mean ± SEM of n = 4 mice per group.
P < .05 versus respective saline group.