Second Crohn disease stem cell transplantation
| Test/symptom . | Before transplantation . | After transplantation . | ||
|---|---|---|---|---|
| 2 mo . | 6 mo . | 12 mo* . | ||
| Diarrhea | Average 10-12 times/d | None | None | None |
| Entry immune suppressive medications | Methotrexate, 6-MP, 5 aminosalicylic acid | None | None | None |
| Hemoglobin, mg/dL (normal, 12-15 mg/dL) | 12 | 12 | 12 | 11.1 |
| CRP (normal, less than 2.5) | 10.8 | 1.1 | 1.4 | 2.4 |
| Sedimentation Rate (normal, less than 20) | 15 | 10 | 10 | 8 |
| Albumin, g/dL (normal, 3.5-5.0 g/dL) | 2.8 | 3.0 | 3.2 | 3.0 |
| CDAI | 271 | 62 | <50 | 60 |
| Small bowel x-ray | Multiple skip areas of inflammation | ND | Normal | Normal |
| Colonoscopy | Severe colitis and terminal ileitis | ND | Slight ulceration of colon | Equivacol colonic ulcerations |
| Colonoscopic biopsy | Severe ulcerations with granulomas | ND | Mild colitis | |
| Test/symptom . | Before transplantation . | After transplantation . | ||
|---|---|---|---|---|
| 2 mo . | 6 mo . | 12 mo* . | ||
| Diarrhea | Average 10-12 times/d | None | None | None |
| Entry immune suppressive medications | Methotrexate, 6-MP, 5 aminosalicylic acid | None | None | None |
| Hemoglobin, mg/dL (normal, 12-15 mg/dL) | 12 | 12 | 12 | 11.1 |
| CRP (normal, less than 2.5) | 10.8 | 1.1 | 1.4 | 2.4 |
| Sedimentation Rate (normal, less than 20) | 15 | 10 | 10 | 8 |
| Albumin, g/dL (normal, 3.5-5.0 g/dL) | 2.8 | 3.0 | 3.2 | 3.0 |
| CDAI | 271 | 62 | <50 | 60 |
| Small bowel x-ray | Multiple skip areas of inflammation | ND | Normal | Normal |
| Colonoscopy | Severe colitis and terminal ileitis | ND | Slight ulceration of colon | Equivacol colonic ulcerations |
| Colonoscopic biopsy | Severe ulcerations with granulomas | ND | Mild colitis | |
CRP indicates C reactive protein; CDAI, Crohn disease activity index (CDAI 250-400, severe disease; CDAI <100, remission); ND, not done.
Patient recovering from “flu” at time of laboratory studies.