Plasma FVIII and VWF levels in MX1cre+LRPflox/flox and control LRPflox/flox mice following pI:pC induction
| Genotype . | Day 10 after pI:pC induction . | Week 6 after pI:pC induction . | ||
|---|---|---|---|---|
| FVIII levels, U/mL . | VWF levels, U/mL . | FVIII levels, U/mL . | VWF levels, U/mL . | |
| Noninduced | 1.9 (1.5-2.4) | 1.2 (1.0-1.6) | 1.5 (0.9-2.3) | 0.8 (0.5-1.1) |
| LRPflox/flox | 2.0 (1.5-2.7) | 1.6 (1.2-2.0) | 1.5 (1.1-1.9) | 0.8 (0.6-1.1) |
| MX1cre+LRPflox/flox | 3.4 (2.4-4.9)* | 2.0 (1.4-2.8)† | 2.1 (1.6-2.9)† | 1.1 (0.8-1.5)† |
| Genotype . | Day 10 after pI:pC induction . | Week 6 after pI:pC induction . | ||
|---|---|---|---|---|
| FVIII levels, U/mL . | VWF levels, U/mL . | FVIII levels, U/mL . | VWF levels, U/mL . | |
| Noninduced | 1.9 (1.5-2.4) | 1.2 (1.0-1.6) | 1.5 (0.9-2.3) | 0.8 (0.5-1.1) |
| LRPflox/flox | 2.0 (1.5-2.7) | 1.6 (1.2-2.0) | 1.5 (1.1-1.9) | 0.8 (0.6-1.1) |
| MX1cre+LRPflox/flox | 3.4 (2.4-4.9)* | 2.0 (1.4-2.8)† | 2.1 (1.6-2.9)† | 1.1 (0.8-1.5)† |
MX1cre+LRPflox/flox mice (n = 29 and 21 for 10 days and 6 weeks after pI:pC induction, respectively) or control LRPflox/flox mice (n = 18 and 9, for 10 days and 6 weeks after pI:pC induction, respectively) were injected 3 times intraperitoneally with 250 μg pI:pC at 2-day intervals. A parallel group of MX1cre+LRPflox/flox littermates were not induced with pI:pC (n = 5 and 6 for 10 days and 6 weeks after pI:pC induction, respectively). At 10 days and 6 weeks after the final pI:pC injection, blood samples were withdrawn and analyzed for plasma factor VIII and VWF, as described in “Materials and methods.” Data represent geometric mean values and 68% confidence intervals.
P < .001, significantly different from control LRPflox/flox mice with the use of the Mann-WhitneyU test.
P < .05, significantly different from control LRPflox/flox mice with the use of the Mann-WhitneyU test.