Relative proportions of CD4+ and CD8+ T lymphocytes in injection-site biopsy specimens
| Lptn dose level . | Patient . | CD4/CD8 ratio . | |
|---|---|---|---|
| Biopsy 1 . | Biopsy 2 . | ||
| 1 | 1 | 2:1 | 16:1 |
| 1 | 2 | 9:1 | NA |
| 1 | 3 | 4:1 | 1:2 |
| 2 | 4 | 5:1 | 16:1 |
| 2 | 5 | 4:1 | 9:1 |
| 2 | 6 | 0.8:1 | 1:1.8 |
| 3 | 7 | 1:3 | NA |
| 3 | 8 | 1:8 | 13:0 |
| 3 | 9 | 2:0 | 1:1.4 |
| 3 | 10 | 1:1 | 1:2 |
| 3 | 11 | 1:4.5 (++) | 1:4 (++) |
| 3 | 12 | 1:1 | 1:7 (+) |
| 3 | 13 | 2.6:1 | 1:1.3 (+) |
| 3 | 14 | 1:2.8 (+++) | 1.7:1 (+++) |
| 3 | 15 | 4:1 | 1:6 (+) |
| 4 | 16 | 4:1 | 1.6:1 (+) |
| 4 | 17 | 1:1.5 | 1.4:1 |
| 4 | 18 | 1:2 | 3:1 |
| 4 | 19 | 1:3 | 1:5 (+++) |
| 4 | 20 | 1:1 | 1:1 |
| 4 | 21 | 1.6:1 (+) | 1:2.6 |
| Control A | 2:1 | NA | |
| Control B | 2:1 | NA | |
| Lptn dose level . | Patient . | CD4/CD8 ratio . | |
|---|---|---|---|
| Biopsy 1 . | Biopsy 2 . | ||
| 1 | 1 | 2:1 | 16:1 |
| 1 | 2 | 9:1 | NA |
| 1 | 3 | 4:1 | 1:2 |
| 2 | 4 | 5:1 | 16:1 |
| 2 | 5 | 4:1 | 9:1 |
| 2 | 6 | 0.8:1 | 1:1.8 |
| 3 | 7 | 1:3 | NA |
| 3 | 8 | 1:8 | 13:0 |
| 3 | 9 | 2:0 | 1:1.4 |
| 3 | 10 | 1:1 | 1:2 |
| 3 | 11 | 1:4.5 (++) | 1:4 (++) |
| 3 | 12 | 1:1 | 1:7 (+) |
| 3 | 13 | 2.6:1 | 1:1.3 (+) |
| 3 | 14 | 1:2.8 (+++) | 1.7:1 (+++) |
| 3 | 15 | 4:1 | 1:6 (+) |
| 4 | 16 | 4:1 | 1.6:1 (+) |
| 4 | 17 | 1:1.5 | 1.4:1 |
| 4 | 18 | 1:2 | 3:1 |
| 4 | 19 | 1:3 | 1:5 (+++) |
| 4 | 20 | 1:1 | 1:1 |
| 4 | 21 | 1.6:1 (+) | 1:2.6 |
| Control A | 2:1 | NA | |
| Control B | 2:1 | NA | |
Eosinophil infiltration was graded as mild (+), moderate (++), or intense (+++).
NA indicates not available.