Follow-up after clinical relapse, depending on the initial quality of response
| Final relapse classification . | n . | Secondary treatment, n . | Result (n) . | Patients taking CSA longer than 9 y . |
|---|---|---|---|---|
| Clinical relapse from CR | ||||
| AA | 11 | 2nd, 5; 3rd, 3; >3rd IST, 2 | CR (9) PR (2) | 2 of 10 |
| No treatment, 1 | ||||
| PNH | 2 | CsA, 1; No treatment, 1 | PR (2) | 1 of 1 |
| MDS | 1 | Supportive, 1 | Death (3) | NA |
| Leukemia | 2 | HSCT, 1; supportive, 1 | ||
| Clinical relapse from PR | ||||
| AA | 12 | 2nd, 7; 3rd, 1; >3rd IST, 1 | CR (2) PR (5) death (5) | 4 of 6 |
| HSCT, 1; No treatment, 2 | ||||
| PNH | 1 | CsA, 1 | PR (1) | 1 of 1 |
| MDS | 1 | Supportive, 1 | Death (1) | NA |
| Final relapse classification . | n . | Secondary treatment, n . | Result (n) . | Patients taking CSA longer than 9 y . |
|---|---|---|---|---|
| Clinical relapse from CR | ||||
| AA | 11 | 2nd, 5; 3rd, 3; >3rd IST, 2 | CR (9) PR (2) | 2 of 10 |
| No treatment, 1 | ||||
| PNH | 2 | CsA, 1; No treatment, 1 | PR (2) | 1 of 1 |
| MDS | 1 | Supportive, 1 | Death (3) | NA |
| Leukemia | 2 | HSCT, 1; supportive, 1 | ||
| Clinical relapse from PR | ||||
| AA | 12 | 2nd, 7; 3rd, 1; >3rd IST, 1 | CR (2) PR (5) death (5) | 4 of 6 |
| HSCT, 1; No treatment, 2 | ||||
| PNH | 1 | CsA, 1 | PR (1) | 1 of 1 |
| MDS | 1 | Supportive, 1 | Death (1) | NA |
Fourteen patients experienced clinical relapse from CR; 16 experienced it from PR. Data for all patients with clinical diagnoses of relapse are shown. They are separated according to the final classification of the disease, causing deterioration of blood counts. Repeated courses of IST included CsA. Six patients were also treated with growth factors. All patients in second or later remission are alive.
NA indicates not applicable.