Six models of inheritance were used, including autosomal dominant with 90% penetrance (D90), autosomal recessive with 100% penetrance (R100), autosomal dominant with 50% penetrance (D50), autosomal dominant with 97% penetrance in women and 42% in men (Dmix), autosomal recessive with 97% penetrance in women and 42% in men (Rmix), and autosomal recessive with 50% penetrance (R50). Lod scores were maximized at each of the 307 markers against distance of a marker from a putative disease gene (theta, θ) and heterogeneity (alpha, α).

Effect exceeds threshold for an established linkage (lod ≥ 3.3) as suggested by Lander and Kruglyak.36 All other effects exceed the threshold for a suggestive linkage (lod ≥ 1.9) as suggested by Lander and Kruglyak.36