Relationship of lupus manifestations to thrombocytopenia in 387 familial lupus patients
| . | Thrombocytopenic . | Nonthrombocytopenic . | ||||||
|---|---|---|---|---|---|---|---|---|
| EA . | AA . | HA . | Total . | EA . | AA . | HA . | Total . | |
| Nephritis | ||||||||
| Present | 11 | 10 | 4 | 25* | 49 | 52 | 6 | 107 |
| Absent | 16 | 5 | 1 | 22 | 157 | 66 | 10 | 33 |
| Neuropsychiatric | ||||||||
| Present | 7† | 3 | 3 | 13‡ | 24 | 21 | 0 | 45 |
| Absent | 20 | 12 | 2 | 34 | 182 | 97 | 16 | 295 |
| AIHA | ||||||||
| Present | 101-153 | 81-155 | 2 | 201-154 | 10 | 11 | 1 | 22 |
| Absent | 17 | 7 | 3 | 27 | 196 | 107 | 15 | 318 |
| . | Thrombocytopenic . | Nonthrombocytopenic . | ||||||
|---|---|---|---|---|---|---|---|---|
| EA . | AA . | HA . | Total . | EA . | AA . | HA . | Total . | |
| Nephritis | ||||||||
| Present | 11 | 10 | 4 | 25* | 49 | 52 | 6 | 107 |
| Absent | 16 | 5 | 1 | 22 | 157 | 66 | 10 | 33 |
| Neuropsychiatric | ||||||||
| Present | 7† | 3 | 3 | 13‡ | 24 | 21 | 0 | 45 |
| Absent | 20 | 12 | 2 | 34 | 182 | 97 | 16 | 295 |
| AIHA | ||||||||
| Present | 101-153 | 81-155 | 2 | 201-154 | 10 | 11 | 1 | 22 |
| Absent | 17 | 7 | 3 | 27 | 196 | 107 | 15 | 318 |
Each manifestation was defined as in the modified ACR criteria.
EA indicates European American; AA, African American; and HA, Hispanic American.
χ2 = 8.7, P = .003, odds ratio = 2.5 (95% confidence interval [CI], 1.4-4.5) compared with nonthrombocytopenic SLE patients.
χ2 = 4.2, P = .04, odds ratio = 2.7 (95% CI, 1.0-6.8) compared with European American nonthrombocytopenic SLE patients.
χ2 = 6.7, P = .009, odds ratio = 2.5 (95% CI, 1.3-5.0) compared with nonthrombocytopenic SLE patients.
χ2 = 31.5, P < .000 01, odds ratio = 11.5 (95% CI, 4.9-27.1) compared with European American nonthrombocytopenic SLE patients.
χ2 = 21.1, P = .0001, odds ratio = 11.1 (95% CI, 4.0-31.2) compared with African American nonthrombocytopenic SLE patients.
χ2 = 55.6, P < 10−10, odds ratio = 10.7 (95% CI, 4.0-31.2) compared with nonthrombocytopenic SLE patients.