Course of acute chest syndrome
| Case no. . | Clinical symptoms . | Lowest Hgb, g/dL (change from baseline) . | O2 saturation on room air (change from baseline) . | Cognitive test scores . | Treatment . | Neurologic symptoms . | MRI findings . |
|---|---|---|---|---|---|---|---|
| 1 | Back pain, fever,*cough | 6.6 (−1.8) | 80% (−16%) | Verbal IQ, 86; performance IQ, 103 | Blood transfusion for 5 y | Frontal headache | RPLS, silent cerebral ischemia |
| 2 | Abdominal, back pain, respiratory distress | 3.7 (−2.7) | 92% (−6%) | Verbal IQ, 73; performance IQ, 73 | Hydroxyurea for 2 mo | Seizure, change in mental status | RPLS, with superimposed ischemia |
| 3 | Fever,*abdominal pain, cardiorespiratory arrest | 5.1 (−3.5) | 89% (−9%) | Verbal IQ, 79; performance IQ, 105 | Blood transfusion for 2 y; currently, on hydroxyurea | Delayed recovery to baseline alertness | RPLS, hemorrhage |
| 4 | Abdominal pain, fever,* respiratory distress | 6.5 (−2.1) | 89% (−11%) | Verbal IQ, 78; performance IQ, 100 | Blood transfusion for 4 mo | Dependent for locomotion and communication | Laminar necrosis and incomplete infarction |
| 5 | Chest, abdominal pain, fever,* respiratory distress | 6.9 (−1.0) | 90% (−5%) | General IQ, 85 | None | Complex partial seizure with secondary generalization | Frontal subarachnoid hemorrhage |
| Case no. . | Clinical symptoms . | Lowest Hgb, g/dL (change from baseline) . | O2 saturation on room air (change from baseline) . | Cognitive test scores . | Treatment . | Neurologic symptoms . | MRI findings . |
|---|---|---|---|---|---|---|---|
| 1 | Back pain, fever,*cough | 6.6 (−1.8) | 80% (−16%) | Verbal IQ, 86; performance IQ, 103 | Blood transfusion for 5 y | Frontal headache | RPLS, silent cerebral ischemia |
| 2 | Abdominal, back pain, respiratory distress | 3.7 (−2.7) | 92% (−6%) | Verbal IQ, 73; performance IQ, 73 | Hydroxyurea for 2 mo | Seizure, change in mental status | RPLS, with superimposed ischemia |
| 3 | Fever,*abdominal pain, cardiorespiratory arrest | 5.1 (−3.5) | 89% (−9%) | Verbal IQ, 79; performance IQ, 105 | Blood transfusion for 2 y; currently, on hydroxyurea | Delayed recovery to baseline alertness | RPLS, hemorrhage |
| 4 | Abdominal pain, fever,* respiratory distress | 6.5 (−2.1) | 89% (−11%) | Verbal IQ, 78; performance IQ, 100 | Blood transfusion for 4 mo | Dependent for locomotion and communication | Laminar necrosis and incomplete infarction |
| 5 | Chest, abdominal pain, fever,* respiratory distress | 6.9 (−1.0) | 90% (−5%) | General IQ, 85 | None | Complex partial seizure with secondary generalization | Frontal subarachnoid hemorrhage |
Fever is defined as temperature >38.5°C.